m^(6)A甲基化修饰环状RNA在肿瘤中的最新研究进展  

Recent research progress in m^(6)A methyladenosine modification of circular RNA in tumors

作　　者：黄未 辛宏亮 林锦鸿 卢佳诚 张靖 HUANG Wei;XIN Hongliang;LIN Jinhong;LU Jiacheng;ZHANG Jing(Shanghai Jiao Tong University School of Medicine,Shanghai 200025;Department of Gastroenterology,Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,China)

机构地区：[1]上海交通大学医学院,上海200025 [2]上海交通大学医学院附属第六人民医院消化内科

出　　处：《胃肠病学和肝病学杂志》2025年第2期271-276,281,共7页Chinese Journal of Gastroenterology and Hepatology

基　　金：上海市自然科学基金项目(21ZR1448700);上海交通大学医学院大学生创新性训练计划(1824077Y)。

摘　　要：环状RNA(circular RNA,circRNA)是一种经反向剪接形成的共价闭合单链RNA分子,具有高度稳定性与进化保守性。功能上,circRNA能够充当微小RNA(microRNA,miRNA)分子海绵、调控基因转录、与功能蛋白相互作用、翻译生成蛋白质等。N6-甲基腺苷(N6-methyladenosine,m^(6)A)修饰是真核细胞中最常见的RNA修饰之一,能够调控RNA的转录、加工、剪接、降解、翻译等过程。近年来,越来越多的证据表明m^(6)A修饰circRNA在肿瘤发生发展中扮演重要角色。本综述简要介绍了m^(6)A修饰circRNA在肿瘤发生发展中的作用及其临床应用。Circular RNA(circRNA)is a single-stranded covalent closed RNA molecule formed by back-splicing,which is highly stable and evolutionarily conserved.Functionally,circRNA can act as microRNA(miRNA)molecular sponges,regulate gene transcription,interact with functional proteins,and generate proteins through translation,etc.N6-methyladenosine(m^(6)A)modification is one of the most common RNA modifications in eukaryotic cells,which can regulate RNA transcription,processing,splicing,degradation,translation and other processes.In recent years,more and more evidences have shown that m^(6)A modified circRNA plays an important role in tumor development.This review briefly introduced the role and clinical application of m^(6)A modified circRNA in tumorigenesis and tumor progression.

关 键 词：环状RNA N6-甲基腺苷修饰 肿瘤 

分 类 号：R735[医药卫生—肿瘤]