lncRNA PVT1在消化系统肿瘤中的研究进展  

Progress of lncRNA PVT1 in digestive system tumors

作　　者：史婷婷 张亚妮 伍杨 朱玲玲 张润兵 张久聪 SHI Tingting;ZHANG Yani;WU Yang;ZHU Lingling;ZHANG Runbing;ZHANG Jiucong(Department of Gastroenterology,the 940th Hospital of Joint Logistics Support Force of PLA,Lanzhou 730050;The First Clinical Medical College of Gansu University of Chinese Medicine;Basic Medical Laboratory,the 940th Hospital of Joint Logistics Support Force of PLA,Gansu Provincial Key Laboratory of Stem Cells and Gene Drugs,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院消化内科,甘肃兰州730050 [2]甘肃中医药大学第一临床医学院 [3]中国人民解放军联勤保障部队第九四〇医院基础医学实验室,甘肃省干细胞与基因药物重点实验室

出　　处：《胃肠病学和肝病学杂志》2025年第2期277-281,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：甘肃省卫生健康行业科研计划项目(GSWSKY2023-34);甘肃中医药大学导师专项(2023YXKY020)。

摘　　要：消化系统肿瘤在我国高发,死亡率极高,严重威胁人体健康,成为目前亟待解决的临床难题。近几年研究发现长链非编码RNA(long non-coding RNA,lncRNA)在消化道肿瘤中发挥了重要作用,lncRNA人浆细胞瘤转化迁移基因1(plasmacytoma variant translocation 1,PVT1)是lncRNA的关键分子,参与了肿瘤细胞的增殖、迁移、侵袭、转化等过程。本文就lncRNA PVT1在消化道肿瘤中的作用和机制进行简要综述,以期为消化道肿瘤的诊断和治疗提供理论依据。Digestive system tumors are highly prevalent in China,with a very high mortality rate,posing a serious threat to human health and becoming a clinical problem that needs to be solved urgently.In recent years,it has been found that long non-coding RNA(lncRNA)plays an important role in digestive tract tumors.LncRNA human plasmacytoma variant translocation 1(PVT1)is a key molecule of lncRNA,which is involved in the proliferation,migration,invasion and transformation of tumor cells.This paper provided a brief review on the role and mechanism of lncRNA PVT1 in digestive tract tumors,with a view to providing a theoretical basis for the diagnosis and treatment of digestive tract tumors.

关 键 词：消化系统肿瘤 lncRNA PVT1 作用机制 

分 类 号：R735[医药卫生—肿瘤]