荆花胃康胶丸联合四联疗法对HP阳性十二指肠溃疡的临床疗效  

Clinical Effect of Jinghuaweikang Capsule Combined with Quadruple Therapy on Patients with HP-Positive Duodenal Ulcer

作　　者：邱兴迪 刘硕 吴品 QIU Xing-di;LIU Shuo;WU Pin(Department of Gastroenterology,First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳医学高等专科学校第一附属医院消化内科,河南南阳473000

出　　处：《罕少疾病杂志》2025年第2期129-131,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 探究幽门螺杆菌(HP)阳性十二指肠溃疡(DU)患者采用荆花胃康胶丸联合四联疗法的临床疗效及对其HP根除率及胃蛋白酶原的影响。方法 按随机数字表法从2021年8月至2023年1月南阳医学高等专科学校第一附属医院收治的HP阳性DU患者中选取106例,分为2组。对照组(n=53例)给予标准四联疗法,即艾司奥美拉唑镁肠溶胶囊+胶体果胶铋胶囊+阿莫西林胶囊+甲硝唑片;观察组(n=53例)在对照组基础上给予荆花胃康胶丸。对比两组HP清除率、血清炎性因子水平、胃蛋白酶原、症状评分、胃肠激素水平。结果 观察组HP转阴率高于对照组;治疗后,观察组超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)和血清转化生长因子β1(TGF-β1)低于对照组;治疗后,观察组胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)低于对照组;治疗后,观察组腹胀、腹痛、反酸和纳差低于对照组;治疗后,观察组生长抑素(SS)、和降钙素基因相关肽(CGRP)高于对照组,胃泌素(GAS)于对照组(P<0.05)。结论 荆花胃康胶丸联合四联疗法对HP阳性DU患者能够有效调节胃蛋白酶原和胃肠激素水平,降低血清炎性因子水平,提高HP清除率,缓解患者临床症状,值得推广。Objective To explore the clinical efficacy of Jinghuaweikang capsule combined with quadruple therapy in patients with Helicobacter pylori(HP)positive duodenal ulcer(DU)and its influence on HP eradication rate and pepsinogen.Methods 106 HP-positive DU patients admitted to the First Affiliated Hospital of Nanyang Medical College from August 2021 to January 2023 were randomly selected and divided into two groups.The control group(n=53 cases)was given the standard quadruple therapy,namely esmomeprazole magnesium enteric-coated capsules+colloidal bismuth pectin capsules+amoxicillin capsules+metronidazole tablets;The observation group(n=53 cases)was given Jinghua Weikang Capsule on the basis of the control group.HP clearance rate,serum inflammatory factors,pepsinogen,symptom score and gastrointestinal hormone levels were compared between the two groups.Results The negative conversion rate of HP in the observation group was higher than that in the control group,as evidenced by the results.Following treatment,levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),and serum transforming growth factorβ1(TGF-β1)were significantly lower in the observation group compared to the control group.Moreover,after treatment,levels of pepsinogenⅠ(PGⅠ)and pepsinogenⅡ(PGⅡ)were notably reduced in the observation group when compared to those in the control group.Additionally,clinical symptoms such as abdominal distension,abdominal pain,acid regurgitation,and anorexia showed significant improvement in the observation group post-treatment.Furthermore,somatostatin(SS)and calcitonin gene-related peptide(CGRP)levels were found to be higher in the observation group compared to those in the control group;however,gastrin(GAS)level was only higher than that observed in controls with statistical significance(P<0.05).Conclusion Jinghuaweikang capsule combined with quadruple therapy effectively regulates pepsinogen levels and gastrointestinal hormones while reducing serum inflammatory factors'concentration.This combinatio

关 键 词：幽门螺杆菌 十二指肠溃疡 荆花胃康胶丸 四联疗法 胃蛋白酶原 

分 类 号：R574.51[医药卫生—消化系统]