Macrophage diversity in cancer dissemination and metastasis  

作　　者：Alberto Mantovani Federica Marchesi Diletta Di Mitri Cecilia Garlanda 

机构地区：[1]IRCCS Humanitas Research Hospital,Rozzano(Milan),Italy [2]Department of Biomedical Sciences,Humanitas University,Pieve Emanuele(Milan),Italy [3]William Harvey Research Institute,Queen Mary University,London,UK [4]Department Medical Biotechnology and Translational Medicine,Universitàdegli Studi di Milano,Milan,Italy

出　　处：《Cellular & Molecular Immunology》2024年第11期1201-1214,共14页中国免疫学杂志(英文版)

基　　金：supported by Associazione Italiana per la Ricerca sul Cancro(AIRC):AIRC 5×100021147 and AIRC IG 23456 to AM,AIRC IG 21714 to CG,AIRC 5×10002019-ID22757 to DDM;the Italian Ministry of Health:RF-2019-12369142 to FM,FRBB Transcan3(JTC2021)to DDM,the Italian Ministry of Education,University and Research:PRIN-2022NKEXAT to CG.

摘　　要：Invasion and metastasis are hallmarks of cancer.In addition to the well-recognized hematogenous and lymphatic pathways of metastasis,cancer cell dissemination can occur via the transcoelomic and perineural routes,which are typical of ovarian and pancreatic cancer,respectively.Macrophages are a universal major component of the tumor microenvironment and,in established tumors,promote growth and dissemination to secondary sites.Here,we review the role of tumor-associated macrophages(TAMs)in cancer cell dissemination and metastasis,emphasizing the diversity of myeloid cells in different tissue contexts(lungs,liver,brain,bone,peritoneal cavity,nerves).The generally used models of lung metastasis fail to capture the diversity of pathways and tissue microenvironments.A better understanding of TAM diversity in different tissue contexts may pave the way for tailored diagnostic and therapeutic approaches.

关 键 词：LIVER Brain BONE 

分 类 号：R73[医药卫生—肿瘤]