脑深部电刺激联合美多芭治疗对帕金森患者疗效以及运动功能的影响  

Effects of deep brain stimulation combined with metoba therapy on the efficacy and motor function of patients with Parkinson's disease

作　　者：赵婧[1] 常克亮[1] 赵鹏 ZHAO Jing;CHANG Ke-Liang;ZHAO Peng(Department of Neurosurgery,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]郑州大学第二附属医院神经外科,郑州450003

出　　处：《医药论坛杂志》2024年第24期2630-2634,共5页Journal of Medical Forum

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190989)。

摘　　要：目的 探讨对帕金森患者使用脑深部电刺激(deep brain stimulation, DBS)联合美多芭治疗的疗效。方法 选取2019年8月—2023年6月郑州大学第二附属医院收治的92例帕金森患者,随机分为对照组和观察组各46例,对照组使用DBS治疗,观察组在此基础联合美多芭治疗,对比疗效、症状、运动功能以及自主神经功能障碍评分。结果 观察组有效率为91.30%,高于对照组的71.74%,差异有统计学意义(P<0.05);治疗前两组症状、抗抑郁及抗焦虑评分比较差异无统计学意义(P>0.05),观察组治疗后帕金森病评定量表(Unified Parkinson's Disease Rating Scale, UPDRS)、汉密尔顿抑郁量表(Hamilton Depression Scale, HAMD)以及汉密尔顿焦虑量表(Hamilton Anxiety Scale, HAMA)评分分别是(42.31±3.63)分、(18.36±4.01)分及(10.54±2.94)分,均低于对照组,差异有统计学意义(P<0.05);治疗前两组运动功能评分比较差异无统计学意义(P>0.05),观察组治疗后上肢、下肢以及总评分分别是(25.08±7.14)分、(46.61±11.38)分及(72.15±20.30)分,均高于对照组,差异有统计学意义(P<0.05);治疗前两组自主神经功能障碍评分比较差异无统计学意义(P>0.05),观察组治疗之后自主神经症状量表(SCOPA-AUT)评分(20.14±3.19)分,低于对照组(22.98±4.72)分,MoCA评分(27.76±2.19)分,明显高于对照组(25.29±3.78)分,差异均有统计学意义(P<0.05)。结论 对帕金森患者使用DBS联合美多芭治疗,可以明显提高治疗效果,改善患者运动功能,值得推广。Objective To investigate the efficacy of deep brain stimulation(DBS) combined with metoba therapy in patients with Parkinson's disease.Methods In a prospective study, 92 patients with Parkinson's disease admitted to the Second Affiliated Hospital of Zhengzhou University from August 2019 to June 2023 were randomly divided into the observation group and the control group. The control group received DBS treatment, and the observation group received metoba treatment on the basis of DBS, and compared the efficacy, symptoms, motor function and autonomic dysfunction scores.Results The effective rate of observation group was 91.30%, which was higher than that of control group(71.74%)(P<0.05). Before treatment, the symptoms, anti-depression and anti-anxiety scores between the two groups with no significantly(P>0.05). After treatment, UPDRS, HAMD and HAMA scores in the observation group were(42.31±3.63) scores,(18.36±4.01) scores and(10.54±2.94) scores, respectively, which were lower than control group(P<0.05).Before treatment, the motor function scores between the two groups with no significantly(P>0.05). After treatment, the scores of upper limbs, lower limbs and total limbs in the observation group were(25.08±7.14) points,(46.61±11.38) points and(72.15±20.30) points, respectively, which were higher than those in the control group(P<0.05).Before treatment, the scores of autonomic dysfunction between the two groups with no significantly(P>0.05). After treatment, the SCOPA-AUT score of the observation group was 20.14±3.19, which was lower than that of the control group(22.98±4.72), and the MoCA score was(27.76±2.19).MoCA score(27.76±2.19) was significantly higher than that of the control group(25.29±3.78),with statistically significant(P<0.05).Conclusion DBS combined with metoba can improve the motor function and therapeutic effect of patients with Parkinson's disease, and it is worth promoting.

关 键 词：帕金森 美多芭 脑深部电刺激 

分 类 号：R742.5[医药卫生—神经病学与精神病学]