肿瘤相关成纤维细胞在消化道肿瘤耐药中的研究进展  

Research progress of cancer-associated fibroblasts in the drug resistance of gastrointestinal cancer

作　　者：朱铮 刘万宁 卢瑗瑗 ZHU Zheng;LIU Wanning;LU Yuanyuan(Battalion 16,No.4 Cadet Regiment,School of Basic Medical Sciences,Xijing Hospital of Digestive Diseases,Air Force Medical University,Xi'an 710032,China;State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases,Xijing Hospital of Digestive Diseases,Air Force Medical University,Xi'an 710032,China;College of Life Sciences,Northwest University,Xi'an 710069,China)

机构地区：[1]空军军医大学基础医学院学员四大队十六队,陕西西安710032 [2]空军军医大学西京消化病医院,国家消化系统疾病临床医学研究中心和消化系肿瘤整合防治全国重点实验室,陕西西安710032 [3]西北大学生命科学学院,陕西西安710069

出　　处：《空军军医大学学报》2025年第2期277-280,F0003,共5页Journal of Air Force Medical University

基　　金：国家自然科学基金面上项目(82273142)。

摘　　要：消化道肿瘤作为常见的恶性肿瘤,严重危害着人类的健康与安全。在肿瘤的治疗过程中,耐药频发限制了各种治疗手段的临床应用。肿瘤微环境作为肿瘤发生发展的“土壤”,其主要组分肿瘤相关成纤维细胞(CAFs)与耐药有着密不可分的联系。因此,本文以CAFs作为切入点,介绍其在消化道肿瘤发生发展中的重要作用并总结CAFs在消化道肿瘤化疗耐药、免疫治疗耐药、放疗耐药以及靶向治疗耐药等方面的相关研究进展,旨在为消化道肿瘤治疗提供新的思路。As a common malignant tumor,gastrointestinal cancer seriously endangers human health and safety.In the course of tumor treatment,frequent drug resistance limits the clinical application of various therapeutic means.Tumor microenvironment is the “soil” of tumor occurrence and development,and its main component,cancer-associated fibroblasts(CAFs),is closely related to drug resistance.Therefore,this paper takes CAFs as the starting point to introduce its important role in the occurrence and development of gastrointestinal cancer,and summarizes the relevant research progress of CAFs in the aspects of chemotherapy resistance,immunotherapy resistance,radiotherapy resistance and targeted therapy resistance,which aims to provide new ideas for the treatment of gastrointestinal cancer.

关 键 词：肿瘤相关成纤维细胞 消化道肿瘤 肿瘤微环境 耐药 

分 类 号：R735[医药卫生—肿瘤]