脂肪肝中的线粒体氧化应激分子机制及营养素干预策略  

Mitochondrial oxidative stress in fatty liver:molecular mechanisms and intervention strategies by nutrients

作　　者：王颖 王一方 罗朝桂 刘健康[1,2] 龙建纲 彭韵桦[1] WANG Ying;WANG YiFang;LUO ChaoGui;LIU JianKang;LONG JianGang;PENG YunHua(Key Laboratory of Biomedical Information Engineering of Ministry of Education,Institute of Mitochondrial Biology and Medicine,School of Life Science and Technology,Xi’an Jiaotong University,Xi’an 710049,China;School of Health and Life Sciences,Rehabilitation University,Qingdao 266071,China)

机构地区：[1]西安交通大学生命科学与技术学院,线粒体生物医学研究所,生物医学信息工程教育部重点实验室,西安710049 [2]康复大学健康与生命科学学院,青岛266071

出　　处：《中国科学:生命科学》2025年第1期67-81,共15页Scientia Sinica(Vitae)

摘　　要：线粒体是真核细胞中发生生物氧化和能量转换以及产生活性氧的主要细胞器,线粒体的稳态平衡保证肝脏等各个器官代谢功能.线粒体氧化应激可以通过损伤线粒体DNA、蛋白质、脂类等生物大分子引发线粒体稳态失衡和线粒体功能障碍并通过影响能量代谢相关信号通路导致脂肪肝病理发生.深入研究线粒体氧化应激参与脂肪肝病理发生的机制有助于发现脂肪肝防治的靶点.本文综述关于线粒体氧化应激的产生及其在脂肪肝病理发生中的作用机制及靶向线粒体的营养素干预策略.Mitochondria are the main organelle in eukaryotic cells that produce biological oxidation,energy conversion and reactive oxygen species.The stable balance of mitochondria ensures the metabolic function of various organs,including the liver.Mitochondrial oxidative stress can damage Mitochondrial DNA,proteins,lipids and other biological macromolecules to cause mitochondrial homeostasis and mitochondrial dysfunction,and lead to the the pathological development of fatty liver by affecting energy metabolism related signal pathways.Further research on the mechanism of mitochondrial oxidative stress in the pathological development of fatty liver can help identify targets for the treatment and prevention of fatty liver.This article reviews the generation of mitochondrial oxidative stress and its mechanism of action in the pathological progression of fatty liver,as well as nutrient intervention strategies targeting mitochondria.

关 键 词：脂肪肝 线粒体 活性氧 氧化应激 

分 类 号：R575.5[医药卫生—消化系统]