艾司氯胺酮在肿瘤患者围术期抑郁症状的研究进展  

Research progress of the perioperative use of S⁃ketamine for depression in tumor patient

作　　者：艾丽非热·艾尔肯 艾来提·塔来提[1] ALFIRA Arkin;AILAITI Talaiti(Department of Anesthesiology,The First Affiliated Hospital of Xinjiang Medical University,Xinjiang Key Laboratory of Perioperative Organ Protection(XJDX1411)Urumqi,Xinjiang,830054,China)

机构地区：[1]新疆医科大学第一附属医院麻醉科新疆围术期器官保护试验室(XJDX1411),新疆乌鲁木齐830054

出　　处：《麻醉安全与质控》2025年第1期82-86,共5页Perioperative Safety and Quality Assurance

基　　金：北京鼎医公益基金会医学科学研究基金(HX2024-2)。

摘　　要：抑郁和肿瘤是全世界两大主要致残性疾病,在肿瘤手术患者中,抑郁症的发生率很高。因此,肿瘤患者之心理康复,也须受到同等重视。艾司氯胺酮已被证实具有快速抗抑郁作用。本文探讨抑郁症在肿瘤患者中的发生现状,回顾艾司氯胺酮抗抑郁机制及其在围术期的应用进展,对艾司氯胺酮在治疗肿瘤手术围术期抑郁症状的可行性及安全性进行综述,为临床提供参考。Depression and tumor are two major deadly diseases worldwide,and researches have confirmed a high incidence of depression among cancer patients.Therefore,while focusing on the physical illnesses of cancer patients,mental health issues should not be over⁃looked.S⁃ketamine has been proven to have rapid antidepressant effects.This article explores the current occurrence of depression in cancer patients,reviews the antidepressant mechanisms of S⁃ketamine and its application progress in the perioperative period,and pro⁃vides a comprehensive review of the feasibility and safety of using S⁃ketamine to treat depression symptoms during tumor surgery,aiming to provide clinical reference.

关 键 词：艾司氯胺酮 肿瘤 围术期 抑郁 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R730[医药卫生—临床医学]