卵巢癌宫颈转移的描述性系统评价  

Descriptive systematic review of cervical metastasis in ovarian cancer

作　　者：高钰美 蔡晶 Gao Yumei;Cai Jing(Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,武汉430022

出　　处：《中国医师杂志》2025年第1期5-10,共6页Journal of Chinese Physician

基　　金：国家自然科学基金(82072891)。

摘　　要：目的系统评价卵巢癌患者发生宫颈转移的临床病理特征和诊疗特点,以期减少误诊、漏诊。方法检索PubMed、Web of Science、CNKI、SinoMed、万方、维普数据库有关卵巢癌宫颈转移的研究,检索时限为建库至2024年9月30日,由2名研究者独立筛选文献、提取资料后,对纳入的研究采用描述性分析方法进行系统评价。结果共纳入21项研究,包括87例患者,其中11篇为个案报道,10篇为回顾性系列病例研究。定性分析显示最常见临床表现是阴道异常出血、排液(61.4%,27/44),病理类型最多见的是高级别浆液性癌(71.4%,40/56),97.0%(33/34)的患者为国际妇产科联盟(FIGO)Ⅲ~Ⅳ期,30.6%(19/62)的患者卵巢原发灶和宫颈转移灶诊断不同步,其中17.7%(11/62)原发灶比转移灶提前6(范围1~26)个月诊断,12.9%(8/62)原发灶则晚了1(范围1~6)个月诊断,总生存期中位值为5个月(范围1/10~120个月)。结论卵巢癌宫颈转移罕见,其临床表现可与原发性宫颈癌类似,鉴别诊断较困难,总体预后不良,及时准确诊断、合理规划治疗卵巢癌的宫颈转移对于患者预后至关重要。Objectives To systematically evaluate the clinicopathological features and diagnosis and treatment characteristics of cervical metastasis in ovarian cancer patients in order to reduce misdiagnosis and missed diagnosis.MethodsStudies on cervical metastasis of ovarian cancer were searched in PubMed,Web of Science,CNKI,SinoMed,Wanfang,and VIP databases,and the search period was from the establishment of the database to September 30,2024.After literature screening and data extraction by two researchers,descriptive analysis was used to systematically evaluate the included studies.ResultsA total of 21 studies were included,including 87 patients,of which 11 were case reports and 10 were retrospective series of case studies.Qualitative analysis showed that the most common clinical manifestations were abnormal vaginal bleeding and drainage(61.4%,27/44).The most common pathological type was high-grade serous carcinoma(71.4%,40/56).97.0%(33/34)of the patients had International Federation of Gynecology and Obstetrics(FIGO)stageⅢtoⅣ.In 30.6%(19/62)of patients,the diagnosis of ovarian primary and cervical metastases was not synchronized.Among them,17.7%(11/62)of the primary lesions were diagnosed 6(range from 1 to 26)months earlier than the metastases.12.9%(8/62)of the primary lesions were diagnosed 1(range from 1 to 6)months later.The median overall survival was 5 months(range 1/10 to 120 months).ConclusionsCervical metastasis of ovarian cancer is rare,its clinical manifestations can be similar to primary cervical cancer,the differential diagnosis is difficult,the overall prognosis is poor,timely and accurate diagnosis,reasonable planning and treatment of cervical metastasis of ovarian cancer are very important for the prognosis of patients.

关 键 词：卵巢肿瘤 肿瘤转移 子宫颈肿瘤 

分 类 号：R73[医药卫生—肿瘤]