晚期卵巢癌腹膜转移的光动力诊断和治疗  

Photodynamic diagnosis and therapy of peritoneal metastases in advanced ovarian cancer

作　　者：刘梦宇 崔普芳 刘琳[1] 郭剑锋 Liu Mengyu;Cui Pufang;Liu Lin;Guo Jianfeng(Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Gynecology,Longhua District People′s Hospital,Shenzhen 518110,China)

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,武汉430022 [2]深圳市龙华区人民医院妇科,深圳518110

出　　处：《中国医师杂志》2025年第1期18-21,27,共5页Journal of Chinese Physician

基　　金：国家自然科学基金(82303128)。

摘　　要：卵巢癌临床表现隐匿,被诊断时常为晚期,多伴有腹膜转移,手术后易复发。与传统的肿瘤治疗方法相比,光动力疗法(PDT)是一种具有微创性和肿瘤靶向特异性的治疗方法,它不仅可以产生光化学反应破坏肿瘤细胞并引发免疫反应,还可以利用其荧光支持光动力诊断和荧光引导手术。临床研究表明,光动力诊断及光动力荧光引导下的肿瘤细胞减灭术、光动力治疗及其联合治疗具有很大的治疗潜力,近年得到认可并逐步推广应用。本文综述了PDT在晚期卵巢癌中的研究和应用现状,并对其可能的应用前景进行了讨论,旨在为临床卵巢癌的综合治疗提供安全、有效的治疗手段。The clinical manifestations of ovarian cancer are occult,often diagnosed as late stage,often accompanied by peritoneal metastasis,and easy to relapse after surgery.Compared with traditional tumor treatment methods,photodynamic therapy(PDT)is a minimally invasive and tumor-targeting specific treatment method,which can not only produce photochemical reactions to destroy tumor cells and trigger immune responses,but also use its fluorescence to support photodynamic diagnosis and fluorescence-guided surgery.Clinical studies have shown that photodynamic diagnosis and photodynamic fluorescence-guided tumor cell reduction,PDT and its combination therapy have great therapeutic potential,and have been recognized and gradually applied in recent years.This article reviews the current status of PDT in the treatment of advanced ovarian cancer,and discusses its possible application prospects in order to provide a safe and effective treatment for the comprehensive treatment of clinical ovarian cancer.

关 键 词：卵巢肿瘤 光动力疗法 光动力诊断 荧光引导手术 光敏剂 

分 类 号：R737.31[医药卫生—肿瘤]