间苯三酚、山莨菪碱及罂粟碱治疗急性胆绞痛的效果和安全性  

Efficacy and safety of Phloroglucinol, Anisodamine and PapaVerine in the treatment of acute biliary colic

作　　者：韦梅洪 容建 张飞 梁郁琼 WEI Meihong;RONG Jian;ZHANG Fei;LIANG Yuqiong(Department of Pharmacy,Gaozhou People's Hospital,Guangdong Province,Gaozhou 525200,China;Department of Emergency,Gaozhou People's Hospital,Guangdong Province,Gaozhou 525200,China)

机构地区：[1]广东省高州市人民医院药剂科,广东高州525200 [2]广东省高州市人民医院急诊科,广东高州525200

出　　处：《中国当代医药》2025年第3期97-100,105,共5页China Modern Medicine

摘　　要：目的评价常见的平滑肌解痉药物的疗效与安全性,为急性胆绞痛的治疗药物选择提供更多合理用药建议。方法选取2022年1月至2024年4月高州市人民医院收治的286例急性胆绞痛患者作为研究对象,按照抽签法分为间苯三酚组(96例)、山莨菪碱组(95例)和罂粟碱组(95例)。间苯三酚组采用间苯三酚治疗,山莨菪碱组采用山莨菪碱治疗,罂粟碱组采用罂粟碱治疗。比较三组患者治疗前后的疼痛评分及药品不良反应发生率。结果三组患者2 h的视觉模拟评分法(VAS)评分比较,差异无统计学意义(P>0.05)。三组患者的疗效比较,差异无统计学意义(P>0.05)。间苯三酚组的药品不良反应总发生率低于山莨菪碱组与罂粟碱组,差异有统计学意义(P<0.017)。结论间苯三酚、山莨菪碱和罂粟碱的解痉治疗效果相当,但安全性方面,间苯三酚的安全性较高,山莨菪碱和罂粟碱的药品不良反应相对前者明显。Objective To evaluate the efficacy and safety of common smooth muscle antispasmolytics,and to provide more rational drug use suggestions for the treatment of acute biliary colic.Methods A total of 286 patients with acute biliary colic treated in Gaozhou People's Hospital from January 2022 to April 2024 were selected as the research subjects,and they were divided into Phloroglucinol group(96 cases),Anisodamine group(95 cases)and PapaVerine group(95 cases)according to drawing lots method.The Phloroglucinol group was treated with Phloroglucinol,the Anisodamine group was treated with Anisodamine,and the PapaVerine group was treated with PapaVerine.The pain scores and the incidence of adverse drug reactions before and after treatment were compared among the three groups.Results There were no significant differences in visual analogue scale(VAS)scores of three groups at 2 h(P>0.05).There was no significant difference in the curative effect of three groups at 2 h(P>0.05).The total incidence of adverse drug reactions in Phloroglucinol group was lower than those in Anisodamine group and PapaVerine group,the differences were statistically significant(P<0.017).Conclusion The antispasmolytic effects of Phloroglucinol,Anisodamine and PapaVerine are similar,but the safety of Phloroglucinol is higher,and the adverse drug reactions of Anisodamine and PapaVerine are more obvious than the former.

关 键 词：胆绞痛 解痉 间苯三酚 山莨菪碱 罂粟碱 

分 类 号：R575[医药卫生—消化系统]