Protective Effects of Pomegranate and Its Bioactive Components on Hepatic Disease  

作　　者：Hong LI Erziya MAI Wenxin ZHENG Yanting HU Zhongrui ZHANG Puyang GONG Jian GU 

机构地区：[1]College of Pharmacy,Southwest Minzu University,Chengdu 400715,China

出　　处：《Medicinal Plant》2025年第1期81-90,共10页药用植物(英文)

基　　金：Supported by the National Natural Science Foundation of China(81573563);Scientific and Technological Innovation Team for Qinghai-Tibetan Plateau Research in Southwest Minzu University(2024CXTD16);the Sichuan Provincial Administration of Traditional Chinese Medicine Innovation Team Project(2023ZD05).

摘　　要：By summarizing the pharmacological effects of pomegranate extract and its active components,such as punicalagin,punicalin,gallic acid,ellagic acid,caffeic acid,and chlorogenic acid,it is found that the extract exhibits therapeutic effects on liver injury,viral hepatitis,metabolic dysfunction-associated fatty liver disease,liver fibrosis,and liver cancer.Emerging evidence suggests that these natural products may alleviate liver diseases through multi-targeted therapeutic mechanisms,including anti-inflammation,anti-oxidative stress,immunoregulation,and anti-steatosis.The underlying mechanisms by which pomegranate exerts hepatoprotective activities may be attributed to the regulation of multiple signaling pathways,including P62/Nrf2,TGF-β1/Smad7,Wnt/β-catenin,MAPK/Nrf2,Nrf2/Keap1,Akt/FOXO3a,MAPK/NF-κB,etc.Consequently,pomegranate can serve as a functional food,nutritional supplement,or adjuvant in the modern treatment of liver diseases.

关 键 词：POMEGRANATE Hepatic disease HEPATOPROTECTIVE Functional food Mechanism of action Pharmacology effect 

分 类 号：R285.5[医药卫生—中药学]