结直肠无蒂锯齿状病变伴异型增生的研究现状  

Current research on sessile serrated lesions with dysplasia

作　　者：张宏业(综述) 李晶[1] 马瑞军(审校)[1] Zhang Hongye;Li Jing;Ma Ruijun(Department of Gastroente-rology and Oncology,Shanxi Provincial People's Hospital,Shanxi Medical University,Shanxi,Taiyuan 030000,China)

机构地区：[1]山西医科大学附属山西省人民医院/山西省人民医院消化肿瘤内科,山西太原030000

出　　处：《疑难病杂志》2025年第2期253-256,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：山西省自然科学研究面上项目(202203021221259)。

摘　　要：锯齿状途径是结直肠癌发生的重要途径之一,无蒂锯齿状病变伴异型增生(SSLD)是无蒂锯齿状病变(SSL)和侵袭性结直肠癌之间的中间阶段,具有显著的临床意义,但由于其病变呈扁平状且进展较迅速,使得检测和诊断SSLD尤为困难,造成间隔癌的发生。目前,越来越多的证据阐明了其特征和生物学特性。文章就目前国内外关于SSLD的内镜下表现、组织学特征、分子机制、微环境及治疗等方面的研究进展进行综合阐述,以期为SSLD的临床诊疗提供理论依据。The serrated pathway is one of the important routes of occurrence of colorectal cancer.Sessile serrated lesions with dysplasia(SSLD)are an intermediate stage between serrated sessile lesion(SSL)and invasive colorectal cancer,with significant clinical significance.However,due to its flat morphology and rapid progression,detecting and diagnosing SSLD is particularly difficult,leading to the occurrence of interval cancers.With increasing evidence,their characteristics and biological characteristics have been clarified.This article comprehensively summarizes the research progress on the endoscopic manifestations,histopathological features,molecular mechanisms,microenvironment,and treatment of SSLD at home and abroad,with the aim of providing theoretical basis for the clinical diagnosis and treatment of SSLD.

关 键 词：结直肠肿瘤 无蒂锯齿状病变伴异型增生 发病机制 诊断 治疗 

分 类 号：R735.3[医药卫生—肿瘤]