贲门腺癌组织中人表皮生长因子受体-2和Ki-67的表达及其对生存的影响  

Expression of human epidermal growth factor receptor-2 and Ki-67 in the gastric cardia adenocarcinoma tissues and the effect on survival

作　　者：史莉莉 黄金 徐瑞华 赵学科[2] 钟侃 王霖瑞 韩雪娜[2] 李爱丽[3] 周福有[4] 李秀敏[5] 马磊[6] 徐全晓[6] 王立东[1,2] SHI Lili;HUANG Jin;XU Ruihua;ZHAO Xueke;ZHONG Kan;WANG Linrui;HAN Xuena;LI Aili;ZHOU Fuyou;LI Xiumin;MA Lei;XU Quanxiao;WANG Lidong(School of Basic Medicine,Zhengzhou University,Zhengzhou 450001,China;State Key Laboratory of Esophageal Cancer Prevention and Treatment,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Oncology,Linzhou Cancer Hospital,Linzhou 456550,China;Department of Thoracic Surgery,Anyang Cancer Hospital,Anyang 455099,China;Department of Gastroenterology,the Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,China;Department of Oncology,the First People's Hospital of Nanyang,Nanyang 473004,China)

机构地区：[1]郑州大学基础医学院,河南郑州450001 [2]郑州大学第一附属医院省部共建食管癌防治国家重点实验室,河南郑州450052 [3]林州市肿瘤医院肿瘤科,河南林州456550 [4]安阳市肿瘤医院胸外科,河南安阳455099 [5]新乡医学院第三附属医院消化内科,河南新乡453003 [6]南阳市第一人民医院肿瘤科,河南南阳473004

出　　处：《肿瘤基础与临床》2024年第6期627-631,共5页journal of basic and clinical oncology

摘　　要：目的 分析贲门腺癌(GCA)组织中人类表皮生长因子受体-2(Her-2)、Ki-67的表达及其对生存的影响。方法 回顾性分析2012年至2022年郑州大学第一附属医院省部共建食管癌防治国家重点实验室收集的行手术切除的1 661例GCA组织标本,采用免疫组化法检测GCA组织中Her-2和Ki-67的表达情况,分析两者表达与临床病理特征、预后的关系。结果 Her-2表达与患者家族史、Lauren分型、淋巴结转移及分化程度有关。GCA组织中Her-2表达和Ki-67的表达呈负相关(r=-0.070,P=0.004)。Kaplan-Meier生存曲线分析显示,Her-2高表达患者总生存率优于低表达患者(χ^(2)=17.918,P<0.001),Ki-67低表达患者总生存率优于高表达患者(χ^(2)=8.530,P=0.004)。COX回归分析显示,年龄、肿瘤大小、Lauren分型、淋巴结转移、浸润程度、Her-2表达及Ki-67表达均是GCA患者预后的独立危险因素。结论 GCA组织中Her-2表达和Ki-67表达呈负相关,Her-2高表达、Ki-67低表达提示患者预后好,联合检测可为GCA患者的治疗及预后评价提供参考。Objective To analyze the expression of human epidermal growth factor receptor-2(Her-2)and Ki-67 in the cancer tissues of patients with gastric cardia adenocarcinoma(GCA),and to explore their associations with survival outcomes.Methods Cancer tissues from 1661 GCA patients who underwent surgical resection from 2012 to 2022 were retrospectively analyzed by the State Key Laboratory of Esophageal Cancer Prevention and Treatment jointly established by the Provincial and Ministry.Immunohistochemical methods were used to detect the expression of Her-2 and Ki-67 in the GCA tissues,and the relationship between their expression and clinicopathological features and prognosis was analyzed.Results Her-2 expression was associated with family history,Lauren classification,lymph node metastasis and differentiation degree.There was a negative correlation between Her-2 expression and Ki-67 expression in the GCA tissues(r=-0.070,P=0.004).Kaplan-Meier survival curve analysis showed that the overall survival rate of patients with high expression of Her-2 was better than that of patients with low expression(χ^(2)=17.918,P<0.001);the overall survival rate of patients with low expression of Ki-67 was better than that of patients with high expression(χ^(2)=8.530,P=0.004).COX regression analysis revealed that age,tumor size,Lauren classification,lymph node metastasis,degree of infiltration,Her-2 expression and Ki-67 expression were the independent prognostic risk factors for GCA.Conclusion High expression of Her-2 suggests a good prognosis,while low expression of Ki-67 suggests a good prognosis,and there is a negative correlation between the expression of Her-2 and Ki-67,their combined assay can provide a reference for the treatment and prognosis evaluation of patients with GCA.

关 键 词：贲门腺癌 人表皮生长因子受体-2 KI-67 临床病理特征 生存期 

分 类 号：R735.2[医药卫生—肿瘤]