NSCLC化疗患者癌因性疲乏与合并心功能不全的相关性分析  

Correlation analysis between cancer-related fatigue and cardiac dysfunction in patients with NSCLC undergoing chemotherapy

作　　者：赵华[1] 董晓丽[1] 赵浩杰 吴丽 祝永月 ZHAO Hua;DONG Xiao-li;ZHAO Hao-jie(Department of Oncology,Baoshan People's Hospital,Baoshan Yunnan 678000,China)

机构地区：[1]保山市人民医院肿瘤科,云南保山678000

出　　处：《临床和实验医学杂志》2025年第2期152-156,共5页Journal of Clinical and Experimental Medicine

基　　金：云南省教育厅科学研究基金项目(编号:2023J0276);保山市人民医院院内科研计划项目(编号:Bsy2021-ky006)。

摘　　要：目的探讨非小细胞肺癌(NSCLC)化疗患者癌因性疲乏(CRF)与合并心功能不全的相关性。方法回顾性选取2022年1月至2024年3月在保山市人民医院进行化疗且发生心功能不全的100例NSCLC患者纳入观察组,另选取同期在本院进行化疗且未发生心功能不全的100例NSCLC患者作为对照组。比较两组患者的临床资料,包括性别、年龄、吸烟史、体重指数、高血压级别、患有糖尿病、病理类型;统计并比较两组患者的实验室指标,包括丙氨酸转氨酶(ALT)、门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(γ-GT)、肌酐、肌酸激酶(CK)、乳酸脱氢酶(LDH)、胱抑素C;统计并比较两组患者的出凝血功能指标,包括血红蛋白、D-二聚体、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、纤维蛋白降解产物(FDP);记录两组患者CRF各项评分及总分。采用多因素Logistic回归分析评估NSCLC化疗患者合并心功能不全的影响因素。结果两组患者在性别、年龄、吸烟史、体重指数、合并糖尿病、病理类型方面比较,差异均无统计学意义(P>0.05);观察组合并高血压患者占比为33.00%,显著高于对照组(20.00%),差异有统计学意义(P<0.05)。两组患者的ALT、AST、γ-GT、肌酐、CK、LDH水平比较,差异均无统计学意义(P>0.05);观察组患者的胱抑素C水平为(1.18±0.17)mg/L,显著高于对照组[(0.97±0.26)mg/L],差异有统计学意义(P<0.05)。观察组患者的血红蛋白、D-二聚体水平分别为(132.81±13.61)g/L、(1.44±0.61)mg/L,均显著高于对照组[(123.85±15.37)g/L、(0.98±0.46)mg/L],差异均有统计学意义(P<0.05);两组患者的PT、APTT、TT、FIB、FDP水平比较,差异均无统计学意义(P>0.05)。观察组患者的情感、行为严重程度、感知、认知及总分分别为(8.32±1.21)、(7.48±1.10)、(7.86±0.95)、(7.60±1.08)、(31.26±1.09)分,均高于对照组[(4.86±0.58)、(4.50±0.54)、(4.02±Objective To investigate the relationship between cancer-induced fatigue and cardiac dysfunction in patients with non-small cell lung cancer(NSCLC)treated with chemotherapy.Methods A total of 100 patients with NSCLC who underwent chemotherapy and had cardiac insufficiency in Baoshan People's Hospital from January 2022 to March 2024 were retrospectively selected as the observation group,and 100 patients with NSCLC who underwent chemotherapy and did not have cardiac insufficiency in the same period were selected as the control group.The clinical data of the two groups were compared,including gender,age,smoking history,body mass index,hypertensive grade,diabetes mellitus and pathological type.The laboratory indicators of the two groups of patients were counted and compared,including the alanine aminotransferase(ALT),aspartate aminotransferase(AST),and gamma-glutamyl transpeptidase(γ-GT),creatine,creatine kinase(CK),lactate dehydrogenase(LDH),cystatin C.The coagulation function indexes of the two groups were analyzed and compared,including hemoglobin,D-dimer,prothrombin time(PT),activated partial thromboplastin time(APTT),and thrombin time(TT),fibrinogen(FIB),fibrinogen degradation product(FDP).The scores and total scores of cancer-related fatigue were recorded in the two groups.The influencing factors of cardiac dysfunction in patients with NSCLC undergoing chemotherapy were evaluated using multiple Logistic regression.Results There were no statistically significant differences in gender,age,smoking history,body mass index,diabetes mellitus and pathological type between the two groups(P>0.05).The proportion of patients with hypertension in the observation group was 33.00%,which was significantly higher than that in the control group(20.00%),and the difference was statistically significant(P<0.05).There was no statistically significant difference in the levels of ALT,AST,γ-GT,creatinine,CK and LDH between the two groups(P>0.05).The level of cystatin C in the observation group was(1.18±0.17)mg/L,which was significa

关 键 词：非小细胞肺癌 化疗 癌因性疲乏 心功能不全 相关性 

分 类 号：R734.2[医药卫生—肿瘤]