Snail和极光激酶A在喉鳞状细胞癌组织中的表达及其与临床病理特征的关系  

Expression of Snail and Aurora A in laryngeal squamous cell carcinoma and their correlation with clinicopathologic features

作　　者：许丽萍 杨文婧 王书谦 郭珊珊 陶倩 XU Li-ping;YANG Wen-jing;WANG Shu-qian(Department of Otolaryngology,Cangzhou People's Hospital,Cangzhou Hebei 061000,China)

机构地区：[1]沧州市人民医院耳鼻喉科,河北沧州061000

出　　处：《临床和实验医学杂志》2025年第2期192-195,共4页Journal of Clinical and Experimental Medicine

基　　金：2021年度河北省医学科学研究课题计划(编号:20211073)。

摘　　要：目的探究喉鳞状细胞癌患者组织中转录因子蛋白Snail、极光激酶A的表达,分析其与临床病理特征的相关性。方法前瞻性选取2020年7月至2024年6月在沧州市人民医院接受手术治疗并经术后病理学诊断确诊的100例喉鳞状细胞癌患者为研究对象。提取患者的喉鳞状细胞癌组织及癌旁组织(距离癌组织2 cm以上的正常组织)进行Snail、极光激酶A检验,对比分析癌组织与癌旁组织、不同临床特征(性别、年龄、临床分型、甲状软骨累及、TNM分期、分化程度、浸润程度、淋巴结转移、远处转移)喉鳞状细胞癌患者的Snail、极光激酶A表达情况。结果癌组织中Snail阳性、极光激酶A阳性占比分别为54.00%、63.00%,均明显高于癌旁组织(12.00%、8.00%),差异均有统计学意义(P<0.05)。Snail阳性表达与性别、年龄、临床分型无关(P>0.05);甲状软骨累及、TNM分期Ⅲ~Ⅳ期、低分化、深层浸润、淋巴结转移、远处转移喉鳞状上皮癌患者的Snail阳性表达率均明显高于甲状软骨未累及、TNM分期Ⅰ~Ⅱ期、中高分化、浅层浸润、无淋巴结转移、无远处转移的患者,差异均有统计学意义(P<0.05)。极光激酶A阳性表达与性别、年龄、临床分型无关(P>0.05);甲状软骨累及、TNM分期Ⅲ~Ⅳ期、低分化、深层浸润、淋巴结转移、远处转移喉鳞状上皮癌患者的极光激酶A阳性表达率均明显高于甲状软骨未累及、TNM分期Ⅰ~Ⅱ期、中高分化、浅层浸润、无淋巴结转移、无远处转移的患者,差异均有统计学意义(P<0.05)。结论Snail、极光激酶A在喉鳞状细胞癌患者组织中均呈现出高表达状态,且随病情加重Snail、极光激酶A阳性表达率有所升高,因此可作为喉鳞状细胞癌早期患者的辅助诊断新指标,辅助提高喉鳞状细胞癌早期确诊率。Objective To investigate the expression of Snail and Aurora A in the tissue of patients with post-squamous cell carcinoma,and to analyze the correlation of clinicopathologic features.Methods A total of 100 patients with laryngeal squamous cell carcinoma who underwent surgical treatment and diagnosed by postoperative pathological diagnosis in Cangzhou People's Hospital from July 2020 to June 2024 were prospectively selected as the study subjects.Snail and Aurora A tests were performed on laryngeal squamous cell carcinoma tissues and paracancerous tissues(normal tissues more than 2 cm away from cancer tissues).The positive expression of Snail and Aurora A in laryngeal squamous cell carcinoma tissues and adjacent tissues were compared.The positive expression rate of Snail and Aurora A in different clinicopathological features(gender,age,clinical classification,thyroid cartilage involvement,TNM stage,degree of differentiation,degree of invasion,lymph node metastasis,distant metastasis)were analyzed.Results The proportions of Snail positive and Aurora A positive in cancer tissues were 54.00%and 63.00%,respectively,which were significantly higher than those in adjacent tissues(12.00%,8.00%),and the differences were statistically significant(P<0.05).The positive expression of Snail was not related to gender,age and clinical classification(P>0.05).The positive expression rate of Snail in laryngeal squamous cell carcinoma patients with thyroid cartilage involvement,TNM stage Ⅲ-Ⅳ,poorly differentiated,deep infiltration,lymph node metastasis and distant metastasis was significantly higher than that in patients without thyroid cartilage involvement,TNM stage Ⅰ-Ⅱ,moderately well differentiated,shallow infiltration,no lymph node metastasis and no distant metastasis,and the differences were statistically significant(P<0.05).The positive expression of Aurora A was not related to gender,age and clinical classification(P>0.05).The positive expression rate of Aurora A in laryngeal squamous cell carcinoma patients with thyro

关 键 词：喉肿瘤 喉鳞状细胞癌 转录因子蛋白 极光激酶A 

分 类 号：R739.65[医药卫生—肿瘤]