血脂和载脂蛋白水平与分化型甲状腺癌及其病理学特征的相关性探究  

Correlation between blood lipid and apolipoprotein levels and differentiated thyroid cancer and its pathological characteristics

作　　者：王杰 张蕾蕾 WANG Jie;ZHANG Leilei(Department of Pathology,Kaifeng 155th Hospital,Kaifeng 475003,Henan,China;Zhang Leilei,Department of Pathology,Huaihe Hospital,Henan University 475000)

机构地区：[1]开封一五五医院病理科,河南开封475003 [2]河南大学淮河医院病理科,河南市475000

出　　处：《航空航天医学杂志》2025年第2期133-135,共3页Journal of Aerospace medicine

摘　　要：目的 分析分化型甲状腺癌患者的载脂蛋白和血脂水平与其发生及临床病理学特征的相关性。方法 选取2020年02月至2023年02月来我院就诊的患有患有分化型甲状腺癌的82例患者设定为观察组。选取80例甲状腺良性结节患者作为对照组。收集对比两组的临床资料;治疗6 m后,采用自动生化检测仪和生化试剂盒检测两组的血脂指标[总胆固醇(Total cholesterol, TC)和甘油三酯(triglyceride, TG)]和[载脂蛋白A1 (apolipoprotein A1, Apo-A1)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin, LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterin, HDL-C)]的水平。结果 观察组患者的TG和TC含量均明显比对照组高(P<0.05),观察组患者的Apo A1含量明显比对照组低(P<0.05)。纳入的影响分化型甲状腺癌发生的多因素变量采用logistic回归分析表明,TC水平与甲状腺癌的发生具有正相关关系(P<0.05),而Apo A1水平与分化型甲状腺癌的发生呈负相关性(P<0.05)。结论 血脂总胆固醇水平和载脂蛋白A1水平与分化型甲状腺癌具有相关性,而载脂蛋白和脂质水平与分化型甲状腺肿瘤的临床病理特点无显著相关性。Objective To analyze the correlation between apolipoprotein and the levels of blood lipid and their occurrence of clinicopathological features in patients with differentiated thyroid cancer.Methods A total of 82 patients with differentiated thyroid cancer admitted in the hospital from February 2020 to February 2023 were chosen as the observation group.A total of 80 patients with benign thyroid nodules were selected as the control group.Clinical data were collected and compared between the two groups;After 6 m of treatment,the blood lipid indexes[total triglyceride(TG)and cholesterol(TC)]and apolipoprotein A1(Apo-A1),high density lipoprotein cholesterin(HDL-C),low density lipoprotein cholesterin(LDL-C).Results The levels of TG and TC in the observation group were significantly higher than those in the control group(P<0.05),and the levels of Apo A1 in the observation group were lower than those in the control group(P<0.05).Logistic regression analysis of the included multivariate variables affecting the occurrence of differentiated thyroid cancer showed that TC level was positively correlated with the occurrence of thyroid cancer(P<0.05),and Apo A1 level was correlated negatively to the incidence of differentiated thyroid cancer(P<0.05).Conclusions Total cholesterol level and Apo-A1 are related to the development of differentiated thyroid cancer,whereas apolipoprotein and lipid levels did not significantly correlate with clinicopathologic features of differentiated thyroid tumors.

关 键 词：载脂蛋白 分化型甲状腺癌 病理学 血脂含量 相关性 

分 类 号：R736.1[医药卫生—肿瘤]