Associations of polycyclic aromatic hydrocarbons exposure with serum uric acid and hyperuricemia in US adults:The role of systemic inflammation  

作　　者：Yang Liu Xuejie Ding Linling Yu Da Shi Ruyi Liang Wei Liu Xuezan Huang Xiuyu Cao Min Zhou Weihong Chen 

机构地区：[1]Department of Occupational and Environmental Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 4300230,China [2]Key Laboratory of Environment and Health,Ministry of Education&Ministry of Environmental Protection,and State Key Laboratory of Environmental Health(Incubating),School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [3]Department of Agricultural,Food,and Nutritional Science,University of Alberta,Edmonton,AB,T6G 2R3,Canada

出　　处：《Journal of Environmental Sciences》2025年第4期412-421,共10页环境科学学报(英文版)

基　　金：supported by the Key Program of National Natural Science Foundation of China(No.82241088);the Natural Science Foundation of Hubei Province(No.2022CFB813).

摘　　要：The associations of polycyclic aromatic hydrocarbon(PAH)exposure with serum uric acid(SUA)or hyperuricemia have been rarely assessed.We aimed to investigate the relationships between urinary PAH metabolites and SUA or hyperuricemia among US adults and to explore the mediating role of systemic inflammation in the associations.A total of 10,307 US adults were conducted to assess the associations of seven urinary hydroxy–PAH with SUA and hyperuricemia and evaluate the role of C-reactive protein(CRP),a biomarker of systemic inflammation,in such associations.Results showed that each 1-unit increase in ln-transformed 2-hydroxynaphthalene(2-OHNa),1-hydroxyphenanthrene(1-OHPh),2&3-hydroxyphenanthrene(2&3-OHPh)and total hydroxyphenanthrene(OHPh)was associated with a 1.68(95%confidence interval(CI):0.19 to 3.17),2.46(0.78 to 4.13),3.34(1.59 to 5.09),and 2.99(1.23 to 4.75)μmol/L increase in SUA,and a 8%(odds ratio(OR):1.08,1.02 to 1.15),9%(OR:1.09,1.02 to 1.18),13%(OR:1.13,1.05 to 1.22),and 12%(OR:1.12,95%CI:1.03,1.21)increase in hyperuricemia,respectively.Co-exposure of seven PAHs was positively associated with SUA and hyperuricemia,with 2&3-OHPh showing the highest weight(components weights:0.83 and 0.78,respectively).The CRP mediated 11.47%and 10.44%of the associations ofΣOHPh and 2&3-OHPh with SUA and mediated 8.60%and 8.62%in associations ofΣOHPh and 2&3-OHPh with hyperuricemia,respectively.In conclusion,internal levels of PAH metabolites were associated with elevated SUA levels and the increased risk of hyperuricemia among US adults,and CRP played a mediating role in the associations.

关 键 词：Polycyclic aromatic hydrocarbon Serum uric acid HYPERURICEMIA C-reactive protein General population 

分 类 号：X592[环境科学与工程—环境工程]