胃部超声造影联合原癌基因c-myb在老年反流性食管炎患者中的应用价值  

Application value of gastric contrast-enhanced ultrasound combined with proto-oncogene c-myb in elderly patients with reflux esophagitis

作　　者：马世拓 汤丽健 戈林 巨丹丹 郑雪 郑绮华 吴冠萌 方军 MA Shi-tuo;TANG Li-jian;GE Lin(Department of Emergency Medicine,Hebei CNPC Central Hospital,Langfang Hebei 065000,China;Department of Health Care and Geriatrics,Hebei CNPC Central Hospital,Langfang Hebei 065000,China;Department of Ultrasound Medicine,Hebei CNPC Central Hospital,Langfang Hebei 065000,China)

机构地区：[1]河北中石油中心医院急诊内科,河北廊坊065000 [2]河北中石油中心医院保健与老年医学科,河北廊坊065000 [3]河北中石油中心医院超声医学科,河北廊坊065000

出　　处：《临床和实验医学杂志》2025年第1期81-84,共4页Journal of Clinical and Experimental Medicine

基　　金：廊坊市科学技术研究与发展计划自筹经费项目(编号:2023013171);河北省医学科学研究课题项目(编号:20201250)。

摘　　要：目的 探索胃部超声造影联合原癌基因c-myb检测在老年反流性食管炎中的应用价值。方法 回顾性选取2022年6月至2023年6月在河北中石油中心医院就诊的102例老年胃食管反流病患者作为研究对象,根据是否发生反流性食管炎分为观察组(n=45,反流性食管炎)和对照组(n=57,无反流性食管炎)。观察反流性食管炎的胃部超声造影检查结果,比较两组患者的c-myb水平差异,并采用受试者操作特征(ROC)曲线评价胃部超声造影联合c-myb指标诊断胃食管反流病患者发生反流性食管炎的价值。结果 经过胃部超声检查结果发现,45例患者中,有40例患者检查出反流性食管炎阳性,胃部超声检查的敏感度为82.22%,特异度为94.74%,阳性预测值为92.50%,阴性预测值为87.10%。观察组患者的c-myb的表达量为1.37±0.21,明显高于对照组(1.02±0.14),差异有统计学意义(P<0.05)。ROC曲线分析结果显示,胃部超声造影、c-myb单独预测老年反流性食管炎的曲线下面积分别为0.885、0.937,敏感度分别为82.22%、84.44%,特异度分别为94.74%、92.98%,而两者联合预测的曲线下面积为0.969,敏感度为88.89%,特异度为94.74%。两者联合预测的曲线下面积均明显高于胃部超声造影、c-myb单独预测。结论 胃部超声造影联合c-myb检测能够提高老年反流性食管炎的诊断效能,是一种可行的辅助诊断方法。且c-myb可能与老年反流性食管炎的发生、发展有关,值得进一步研究。Objective To explore the application value of gastric contrast-enhanced ultrasound combined with proto-oncogene c-myb detection in elderly patients with reflux esophagitis.Methods A total of 102 elderly patients with gastroesophageal reflux disease who were treated in Hebei CNPC Central Hospital from June 2022 to June 2023 were retrospectively selected as the research objects.According to whether reflux esophagitis occurred,they were divided into the observation group(n=45,reflux esophagitis)and the control group(n=57,no reflux esophagitis).The results of gastric contrast-enhanced ultrasonography of reflux esophagitis were observed,and the difference of c-myb level between the two groups was compared.The receiver operating characteristic(ROC)curve was used to evaluate the value of gastric contrast-enhanced ultrasonography combined with c-myb index in the diagnosis of reflux esophagitis in patients with gastroesophageal reflux disease.Results The results of gastric ultrasonography showed that 40 of the 45 patients had positive reflux esophagitis.The sensitivity of gastric ultrasonography was 82.22%,the specificity was 94.74%,the positive predictive value was 92.50%,and the negative predictive value was 87.10%.The expression of c-myb in the observation group was 1.37±0.21,which was significantly higher than that in the control group(1.02±0.14),and the difference was statistically significant(P<0.05).The results of ROC curve analysis showed that the area under the curve of gastric contrast-enhanced ultrasound and c-myb alone in predicting reflux esophagitis in the elderly was 0.885 and 0.937,respectively,the sensitivity was 82.22%and 84.44%,respectively,and the specificity was 94.74%and 92.98%,respectively.The area under the curve of the combined prediction of the two was 0.969,the sensitivity was 88.89%,and the specificity was 94.74%.The area under the curve of the combined prediction was significantly higher than that of gastric contrast-enhanced ultrasound and c-myb alone.Conclusion Gastric contrast-enhanced ul

关 键 词：老年 反流性食管炎 胃镜 胃部超声造影 原癌基因c-myb 

分 类 号：R57[医药卫生—消化系统]