基于“伏邪学说”探讨铁死亡在冠状动脉粥样硬化性心脏病中的调控机制及中医药干预  

Exploration of the regulatory mechanism of ferroptosis in coronary atherosclerotic heart disease based on the"latent pathogen theory"and Chinese medicine intervention

作　　者：柳岳 张书萌 陆玉雯 刘映志 陈伶利[1] 李杰[1] LIU Yue;ZHANG Shumeng;LU Yuwen;LIU Yingzhi;CHEN Lingli;LI Jie(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2025年第2期318-324,共7页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金(81874375);湖南省自然基金课题(2023JJ30452);湖南省中医药科研重点课题(C2023002);湖南中医药大学研究生创新课题(2024CX150,2024CX151,2024CX152);湖南省普通高等学校科技创新团队支持项目。

摘　　要：冠状动脉粥样硬化性心脏病简称冠心病(CHD),在全球范围内其高发病率和高死亡率严重威胁人类健康。铁死亡作为一种特征为铁依赖性脂质过氧化的新型细胞死亡方式,在细胞形态学与生物化学特性上区别于传统的细胞死亡模式。铁过载与脂质过氧化物的积累等机制,符合中医理论中的“伏邪”概念,被视为促进铁死亡发生的重要因素,进而加剧了动脉粥样硬化的病理进程。本文基于“伏邪学说”的视角,探究铁死亡在CHD发病机制中的调控作用,分析中药及中药复方对铁死亡过程的干预效果,旨在为中医药在CHD的防治领域提供新的理论见解与实践依据。Coronary atherosclerotic heart disease,also known as coronary heart disease(CHD),is a major global health concern due to its high incidence and mortality rates.Ferroptosis,a novel form of cell death characterized by iron-dependent lipid peroxidation,differs from traditional cell death modes in terms of its morphological and biochemical characteristics.Mechanisms such as iron overload and the accumulation of lipid peroxides,which correspond to the concept of"latent pathogen"in Chinese medicine,are considered important factors that promote ferroptosis,further exacerbating the pathological progression of atherosclerosis.This article,from the perspective of the"latent pathogen theory",explores the regulatory role of ferroptosis in the pathogenesis of CHD and analyzes the intervention effects of Chinese medicine and herbal formulas on the ferroptosis process,so as to provide new theoretical insights and practical evidence for the prevention and treatment of CHD using Chinese medicine.

关 键 词：伏邪学说 冠状动脉粥样硬化性心脏病 铁死亡 脂质过氧化 铁过载 

分 类 号：R256.2[医药卫生—中医内科学]