多模态MRI无创量化诊断颞叶癫痫的效能探究  

Efficacy of Multimodal MRI in Non-invasive Quantitative Diagnosis of Temporal Lobe Epilepsy

作　　者：王艳[1] 鲁豫 邢俊领[2] 张正艳[3] 郭兆红[4] 邢红霞 WANG Yan;LU Yu;XING Jun-ling;ZHANG Zheng-yan;GUO Zhao-hong;XI G Hong-xia(Second Ward,Department of Neurology,the third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China;Department of Neurosurgery,the third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China;Electroencephalogram room,the third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China;School of Health Management,Xinxiang Medical University,Xinxiang 453003,Henan Province,China;third Ward,Department of Neurology,the third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China)

机构地区：[1]新乡医学院第三附属医院神经内科二病区,河南新乡453003 [2]新乡医学院第三附属医院神经外科,河南新乡453003 [3]新乡医学院第三附属医院脑电图室,河南新乡453003 [4]新乡医学院卫生健康管理学院,河南新乡453003 [5]新乡医学院第三附属医院神经内科三病区,河南新乡453003

出　　处：《中国CT和MRI杂志》2025年第2期29-31,共3页Chinese Journal of CT and MRI

基　　金：2023年河南省自然科学基金项目(232300420061);河南省高等教育教学改革研究与实践项目(2023SJGLX240Y)。

摘　　要：目的 分析多模态磁共振成像(MRI)无创量化对颞叶癫痫(TLE)的诊断效能。方法 选取2017年1月至2024年3月期间我院收治的48例癫痫患者为研究组,另选取40例同期体检健康志愿者为对照组,受试对象均行多模态MRI检查,包括弥散加权成像(DWI)、弥散张量成像(DTI)及氢质子磁共振波谱成像(1H-MRS),对比两组多模态MRI无创量化参数,采用多因素Logisitic回归分析TLE发生的危险因素,并采用受试者工作特征(ROC)曲线分析多模态MRI无创量化参数对TLE的诊断价值。结果 研究组ADC高于对照组,FA、NAA/Cr、NAA/Cho、NAA/(Cr+Cho)低于对照组(P<0.05)。多因素Logistic回归分析结果显示ADC、FA、NAA/Cr、NAA/Cho、NAA/(Cr+Cho)均为TLE发生的影响因素(P<0.05)。ROC曲线分析结果显示,ADC、FA、NAA/Cr、NAA/Cho、NAA/(Cr+Cho)联合诊断TLE的曲线下面积(AUC)最高为0.919,具有较好的诊断效能。结论 多模态MRI无创量化参数ADC、FA、NAA/Cr、NAA/Cho、NAA/(Cr+Cho)与TLE发生显著相关,为TLE诊断提供有效量化参考依据。Objective To analyze the efficacy of multimodal magnetic resonance imaging(MRI) in non-invasive quantitative diagnosis of temporal lobe epilepsy(TLE). Methods A total of 48 patients with epilepsy admitted to the hospital from January 2017 to March 2024 were selected as the study group.Meanwhile, 40 healthy volunteers were selected as the control group. All subjects underwent multimodal MRI examinations, including diffusion-weighted imaging(DWI), diffusion-tensor imaging(DTI) and proton magnetic resonance spectroscopy(~1H-MRS). The non-invasive quantitative parameters of multimodal MRI were compared between the two groups, and multivariate logistic regression analysis was conducted to identify the risk factors for TLE.The diagnostic value of non-invasive quantitative parameters of multimodal MRI for TLE was analyzed using receiver operating characteristic(ROC) curves. Results Compared with the control group, the ADC value was higher,and FA, NAA/Cr, NAA/Cho and NAA/(Cr+Cho) were lower in the study group(P<0.05). Multivariate logistic regression analysis results showed that ADC, FA, NAA/Cr,NAA/Cho, and NAA/(Cr+Cho) were factors influencing the occurrence of TLE(P<0.05).ROC curve analysis results showed that the area under the curve(AUC) of joint diagnosis of TLE using ADC, FA, NAA/Cr,NAA/Cho and NAA/(Cr+Cho) was the highest(0.919), indicating good diagnostic efficacy. Conclusion The non-invasive quantitative parameters [ADC, FA, NAA/Cr,NAA/Cho and NAA/(Cr+Cho)] of multimodal MRI are markedly correlated with the occurrence of TLE, providing effective reference for the diagnosis of TLE.

关 键 词：颞叶癫痫 多模态磁共振成像 诊断 无创量化 

分 类 号：R742.1[医药卫生—神经病学与精神病学]