磁性铁氧体纳米颗粒应用于放疗中的研究进展  

Advances in research on the application of magnetic ferrite nanoparticles in radiotherapy

作　　者：王亮[1] 林海磊[2] 吉艳琴[1] Wang Liang;Lin Hailei;Ji Yanqin(Key Laboratory of Radiological Protection and Nuclear Emergency,China CDC,National Institute for Radiological Protection,Chinese Center for Disease Control and Prevention,Beijing 100088,China;Department of Radiation Oncology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国疾病预防控制中心辐射防护与核安全医学所,辐射防护与核应急中国疾病预防控制中心重点实验室,北京100088 [2]北京医院放疗科,国家老年医学中心,中国医学科学院老年医学研究院,北京100730

出　　处：《中华放射医学与防护杂志》2025年第1期74-79,共6页Chinese Journal of Radiological Medicine and Protection

摘　　要：危及器官的放射不良反应是限制临床靶区剂量的重要因素。磁性铁氧体纳米颗粒具有易于修饰及高生物相容性等特别的理化性质,在生物医学领域得到广泛研究。本文综述了磁性铁氧体纳米颗粒通过磁热效应、剂量增强效应、促进铁死亡、调节细胞周期、提高图像引导质量等方面应用于放疗相关研究的最新进展,并对未来的研究提出了展望。Radiation⁃induced adverse reactions in organs at risk(OAR)is recognized as a significant factor limiting doses to clinical target volumes(CTV).Magnetic ferrite nanoparticles,distinguished by their unique physicochemical properties such as ease of modification and high biocompatibility,have been extensively investigated in the biomedical field.This article reviews the latest advances in research on the application of magnetic ferrite nanoparticles in radiotherapy,focusing on their magnetothermal effect,dose enhancement effect,promotion of ferroptosis,regulation of the cell cycle,and improvement in image⁃guided quality.Furthermore,this article provides an outlook for future research.

关 键 词：磁性铁氧体纳米颗粒 恶性肿瘤 放射疗法 放射敏感性 

分 类 号：R730.55[医药卫生—肿瘤]