Near-infrared carbon dots:pioneering emerging frontiers in biomedical applications  

近红外碳点:开创生物医学应用的新前沿

作　　者：HE Qian YANG Yan-li LI Rui-jiao MA Dan ZHANG Li-yun 贺倩;杨艳丽;李瑞娇;马丹;张莉芸(山西医科大学第三医院,山西白求恩医院(山西医学科学院),同济山西医院,太原030032)

机构地区：[1]Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,China

出　　处：《新型炭材料(中英文)》2025年第1期131-153,共23页New Carbon Materials

基　　金：financial support by Talent Introduction Research Initiation Fund of Shanxi Bethune Hospital(2022RC04);Basic Research Program Youth Science Research Project of Shanxi province(202203021212096);Shanxi Province Clinical Theranostics Technology Innovation Center for Immunologic and Rheumatic Diseases(CXZX-202302);Research Project Plan of Shanxi Provincial Administration of Traditional Chinese Medicine(2023ZYYB2021)。

摘　　要：Carbon dots(CDs)are fluorescent carbon-based nanomaterials with sizes smal-ler than 10 nm,that are renowned for their exceptional properties,including superior anti-photobleaching,excellent biocompatibility,and minimal toxicity,which have received sig-nificant interest.Near-infrared(NIR)light has emerged as an ideal light source in the biolo-gical field due to its advantages of minimal scattering and absorption,long wavelength emission,increased tissue penetration,and reduced interference from biological back-grounds.CDs with efficient absorption and/or emission characteristics in the NIR spectrum have shown remarkable promise in the biomedical uses.This study provides a comprehens-ive overview of the preparation methods and wavelength modulation strategies for near-in-frared CDs and reviews research progress in their use in the areas of biosensing,bioimaging,and therapy.It also discusses current challenges and clinical prospects,aimed at deepening our understanding of the subject and promoting further advances in this field.碳点(CDs)是直径小于10 nm的荧光碳基纳米材料,以其优异的抗光漂白能力、良好的生物相容性和低毒性等,引起了广泛关注。近红外(NIR)光由于具有较小的光散射和吸收、长波长发射、深层组织穿透能力以及对生物背景干扰小等优点,已成为生物领域的理想选择。特别是表现出高效吸收和/或发射特性的近红外碳点在生物医学领域展现出显著的潜力。因此,本研究全面概述了近红外碳点(NIR-CDs)的制备方法及波长调控策略,并系统回顾了NIR-CDs在生物传感、活体成像和治疗等领域的研究进展。此外,本文还讨论了NIR-CDs当前面临的挑战及临床前景,旨在加深研究者的理解,推动这一新兴领域的进一步发展。

关 键 词：Near-infrared carbon dots BIOIMAGING BIOSENSING Therapy BIOMEDICINE 

分 类 号：TQ127.11[化学工程—无机化工]