急性胰腺炎患者血清HMGB1、ICAM-1水平与APACHEⅡ、BISAP评分的相关性分析  

Correlation Analysis of Serum HMGB1 and ICAM-1 Levels with APACHEⅡand BISAP Scores in Patients with Acute Pancreatitis

作　　者：王妮娟 刘佳 WANG Nijuan;LIU Jia(Baoji Hospital Affiliated to Xi'an Medical College,Baoji Shaanxi 721000)

机构地区：[1]西安医学院附属宝鸡医院全科医学科,陕西宝鸡721000 [2]榆林市第一医院体检中心,陕西榆林719000

出　　处：《医学临床研究》2025年第1期16-19,共4页Journal of Clinical Research

摘　　要：【目的】探讨急性胰腺炎患者血清高迁移率族蛋白1(HMGB1)、细胞间黏附分子-1(ICAM-1)水平与急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)、急性胰腺炎严重程度床边指数(BISAP)评分的相关性。【方法】选择2020年4月至2022年4月西安医学院附属宝鸡医院收治的80例急性胰腺炎患者,根据患者病情严重程度将其分为轻度组(n=39)、中度组(n=23)、重度组(n=18)。另选在本院接受体检的80例健康志愿者(健康组),比较四组血清HMGB1、ICAM-1、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平,以及APACHEⅡ、BISAP评分,分析四组血清HMGB1、ICAM-1与CRP、TNF-α、IL-6、APACHEⅡ评分、BISAP评分的相关性。【结果】四组APACHEⅡ评分比较,健康组<轻度组<中度组<重度组,差异有统计学意义(P<0.05)。三组患者BISAP评分呈递增趋势,轻度组<中度组<重度组,差异有统计学意义(P<0.05)。四组血清HMGB1、ICAM-1、CRP、TNF-α、IL-6水平比较,健康组<轻度组<中度组<重度组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,血清HMGB1、ICAM-1水平与血清CRP、TNF-α、IL-6水平,以及APACHEⅡ评分、BISAP评分均呈正相关(P<0.05)。【结论】血清HMGB1、ICAM-1水平与急性胰腺炎患者的病情严重程度相关,临床医师可通过检测血清HMGB1、ICAM-1水平评估患者病情严重程度。【Objective】To investigate the correlation between serum levels of high mobility group 1 protein(HMGB1)and intercellular adhesion molecule-1(ICAM-1)in patients with acute pancreatitis with acute physiology and chronic health status evaluationⅡ(APACHEⅡ)and bedside index of acute pancreatitis severity(BISAP)scores.【Methods】Eighty patients with acute pancreatitis admitted to our hospital from April 2020 to April 2022 were selected and divided into the mild group(n=39),moderate group(n=23),and severe group(n=18)according to the severity of their condition.Another 80 healthy volunteers who underwent physical examinations in our hospital were selected as the healthy group.Levels of serum HMGB1,ICAM-1,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),as well as APACHEⅡand BISAP scores were compared among the four groups.The correlation of serum HMGB1 and ICAM-1 levels with CRP,TNF-α,IL-6,APACHEⅡscore,and BISAP score was analyzed among the four groups.【Results】The APACHEⅡscores of the four groups were shown in the order of the healthy group<the mild group<the moderate group<the severe group;And the difference was statistically significant(P<0.05).The BISAP scores of the three groups of patients showed an increasing trend with the mild group<the moderate group<the severe group,and the difference was statistically significant(P<0.05).The comparison of serum levels of HMGB1,ICAM-1,CRP,TNF-α,and IL-6 in the four groups showed that the healthy group was least followed by the order of the mild group<the moderate group<the severe group,with statistically significant differences(P<0.05).Pearson correlation analysis showed that serum levels of HMGB1 and ICAM-1 were positively correlated with serum levels of CRP,TNF-α,IL-6,as well as APACHEⅡscore and BISAP score(P<0.05).【Conclusion】The levels of serum HMGB1 and ICAM-1 are correlated with the severity of acute pancreatitis in patients.Clinical physicians can evaluate the severity of patients'condition by detecting the levels

关 键 词：胰腺炎 急性病 高迁移率族蛋白质类 细胞黏附分子 急性生理学和慢性健康状况评价Ⅱ 

分 类 号：R576.1[医药卫生—消化系统]