血清YKL-40、Hcy、UA及BDNF水平与帕金森病患者认知功能的相关性研究  

Correlation of Serum YKL-40, Hcy, UA, and BDNF Levels with Cognitive Function in Patients with Parkinson's Disease

作　　者：高源 田凤[1] GAO Yuan;TIAN Feng(Department of Neurology,The First Affiliated Hospital of Shihezi University,Shihezi Xinjiang 832000)

机构地区：[1]石河子大学第一附属医院神经内科,新疆石河子832000

出　　处：《医学临床研究》2025年第1期23-26,共4页Journal of Clinical Research

基　　金：石河子大学科研项目(ZZZC2022069)。

摘　　要：【目的】探讨血清人软骨糖蛋白39(YKL-40)、同型半胱氨酸(Hcy)、血尿酸(UA)及脑源性神经营养因子(BDNF)水平与帕金森病(PD)患者认知功能的关系。【方法】113例PD患者,依据是否伴有认知功能障碍分为认知障碍组(A组,n=62)和认知无障碍组(B组,n=51),并将A组患者分为轻度组(n=34)、中度组(n=18)和重度组(n=10)。比较A组和B组、不同认知障碍程度患者血清YKL-40、Hcy、UA及BDNF水平,分析其预测认知功能障碍的价值;采用相关性分析血清YKL-40、Hcy、UA及BDNF水平与认知功能障碍程度的关系。【结果】A组患者血清YKL-40、Hcy水平均高于B组,UA、BDNF水平均低于B组(P<0.05)。受试者工作特征曲线分析显示,血清YKL-40、Hcy、UA及BDNF水平预测患者认知功能障碍的最佳截断值分别为4.015 mg/mL、24.930μmol/L、296.235μmol/L、11.195 ng/mL(均P<0.05)。重度组患者血清YKL-40、Hcy水平高于轻度组、中度组,UA、BDNF水平低于轻度组、中度组(P<0.05);中度组患者血清YKL-40、Hcy水平高于轻度组,UA、BDNF水平低于轻度组(P<0.05)。相关性分析显示,血清YKL-40、Hcy水平与认知障碍程度均呈正相关(P<0.05),血清UA、BDNF水平与认知障碍程度均呈负相关(P<0.05)。【结论】伴有认知障碍的PD患者血清YKL-40、Hcy水平显著升高,UA、BDNF水平显著降低,并与患者认知障碍程度密切相关。【Objective】To investigate the relationship of serum levels of human cartilage glycoprotein 39(YKL-40),homocysteine(Hcy),uric acid(UA),and brain-derived neurotrophic factor(BDNF)with cognitive function in patients with Parkinson's disease(PD).【Methods】A total of 113 PD patients were enrolled.According to the presence or absence of cognitive impairment,they were divided into a cognitive impairment group(Group A,n=62)and a non-cognitive impairment group(Group B,n=51).Patients in Group A were further classified into a mild group(n=34),a moderate group(n=18),and a severe group(n=10)based on the severity of cognitive impairment.The serum levels of YKL-40,Hcy,UA,and BDNF were compared between Groups A and B and analyzed among sub-groups of patients with different degrees of cognitive impairment as well.The predictive value for cognitive impairment was analyzed,and the correlations between these serum indicators and the degree of cognitive impairment were further examined.【Results】Serum YKL-40 and Hcy levels in Group A were significantly higher than those in Group B,whereas serum UA and BDNF levels were significantly lower than those in Group B(P<0.05).Receiver operating characteristic curve analysis showed that the optimal cutoff values YKL-40,Hcy,UA,BDNF for predicting cognitive impairment were 4.015 mg/mL,24.930μmol/L,296.235μmol/L,and 11.195 ng/mL(all P<0.05).In the severe subgroup,serum YKL-40 and Hcy levels were higher and UA and BDNF levels were lower than those in both mild and moderate subgroups(P<0.05).In the moderate subgroup,serum YKL-40 and Hcy levels were higher and UA and BDNF levels were lower than those in the mild subgroup(P<0.05).Correlation analysis showed that serum YKL-40 and Hcy levels were positively correlated with the degree of cognitive impairment(P<0.05),whereas serum UA and BDNF levels were negatively correlated with the degree of cognitive impairment(P<0.05).【Conclusion】PD patients with cognitive impairment exhibit notably elevated serum YKL-40 and Hcy levels as well as dec

关 键 词：帕金森病 认知 软骨蛋白聚糖类 半胱氨酸 尿酸 脑源性神经营养因子 

分 类 号：R742.5[医药卫生—神经病学与精神病学]