复神灵窍汤治疗痰气郁结型精神分裂症的疗效  

Observation of Therapeutic Effect of Fushen Lingjiao Decoction in the Treatment of Tanqi Yujie Schizophrenia

作　　者：刘挺 李琼 LIU Ting;LI Qiong(The First Affiliated Hospital of Xi'an Jiaotong University,Yulin Hospital,Yulin Shaanxi 719000)

机构地区：[1]西安交通大学第一附属医院榆林医院,陕西榆林719000

出　　处：《医学临床研究》2025年第1期30-33,共4页Journal of Clinical Research

摘　　要：【目的】探讨复神灵窍汤治疗痰气郁结型精神分裂症的疗效。【方法】选择2022年9月至2023年3月本院收治的80例痰气郁结型精神分裂症患者,采用随机数字表法将其分为对照组(常规西药治疗)和观察组(在对照组的基础上联合复神灵窍汤治疗),每组40例。比较两组临床疗效、阳性和阴性症状量表(PANSS)评分、洛文斯顿作业疗法认知评定量表(LOTCA)评分、神经功能指标[脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)、5-羟色胺(5-HT)]、内分泌功能指标[褪黑素(MT)、促甲状腺激素(TSH)、多巴胺(DA)]以及不良反应发生情况。【结果】观察组临床有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组PANSS评分低于治疗前,LOTCA评分高于治疗前,且观察组PANSS评分低于对照组,LOTCA评分高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清BDNF、5-HT水平高于治疗前,NSE水平低于治疗前,且观察组血清BDNF、5-HT水平高于对照组,NSE水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清MT、TSH、DA水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为15.00%(6/40),与对照组的7.50%(3/40)比较,差异无统计学意义(P>0.05)。【结论】复神灵窍汤联合常规西药治疗痰气郁结型精神分裂症的疗效显著,可明显改善患者临床症状及认知功能,调节神经功能及内分泌功能,且安全性较好,值得临床推广。【Objective】To investigate the efficacy and clinical value of Fushen Lingqiao decoction in the treatment of Tanqi Yujie schizophrenia.【Methods】A total of 80 patients with Tanqi Yujie schizophrenia who were admitted to our hospital from September 2022 to March 2023 were randomly divided into the control group(treated with conventional western medicine)and the observation group(treated with Fushen Lingqiao decoction on the top of the control group),with 40 cases in each group.The clinical efficacy,positive and negative symptom scale(PANSS)scores,Lowingston Occupational Therapy Cognitive Rating Scale(LOTCA)score,neurological function[brain-derived neurotrophic factor(BDNF),neuron-specific enolase(NSE),serotonin(5-HT)],endocrine function[melatonin(MT),thyroid-stimulating hormone(TSH),dopamine(DA)]and adverse reactions were compared between the two groups.【Results】The clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the PANSS scores of the two groups were lower than those before treatment,their LOTCA scores were higher than those before treatment.The PANSS score of the observation group was lower than that of the control group,and the LOTCA score of the observation group was higher than that of the control group.The differences were statistically significant(P<0.05).After treatment,the serum levels of BDNF and 5-HT in the two groups were higher than those before treatment,and the NSE level was lower than before treatment.The levels of NSE in the observation group were higher than those in the control group,while the level of NSE in the observation group was lower than that in the control group.The differences were statistically significant(P<0.05).After treatment,the serum levels of MT,TSH and DA in the two groups were higher than those before treatment,and levels of MT,TSH and DA in the observation group was higher than those in the control group.The differences were statistically significant(P<0.

关 键 词：精神分裂症 中西药合用 治疗结果 

分 类 号：R749.3[医药卫生—神经病学与精神病学]