^(18)F-FDG PET/CT动态显像在肺癌中的临床应用进展  

Clinical application progress of ^(18)F-FDG PET/CT dynamic imaging in lung cancer

作　　者：周锦朋 西尔艾力·吾门尔 杜芬 梁颖 Zhou Jinpeng;Xieraili Wumener;Du Fen;Liang Ying(Department of Nuclear Medicine,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116,China;PET/CT Center,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院深圳医院核医学科,深圳518116 [2]国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院PET/CT中心,北京100021

出　　处：《中华核医学与分子影像杂志》2025年第1期48-52,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：深圳市高水平医院建设专项。

摘　　要：^(18)F-FDG PET/CT静态显像在肺癌的诊断、分期和疗效评估中具有重要作用。通过SUV等代谢参数进行半定量分析,为临床提供了重要的代谢信息。但SUV易受患者因素、采集时间和重建算法等的影响。动态显像可连续评估在一段时间内病变的代谢变化,利用净摄取速率常数等动态参数进行定量分析。动态显像为静态显像提供了重要的补充信息,为肺癌诊治提供了更为精准的信息。该文就^(18)F-FDG PET/CT动态显像在肺癌诊断、淋巴结分期、免疫治疗疗效预测及评估、优化扫描方案中的研究进展展开综述。^(18)F-FDG PET/CT static imaging plays a crucial role in the diagnosis,staging,and efficacy assessment of lung cancer.Semi-quantitative analysis using metabolic parameters,such as SUV,provide essential metabolic information for clinical decision-making.However,SUV is influenced by patient factors,acquisition time,and reconstruction algorithms.Dynamic imaging allows continuous assessment of the metabolic changes in lesions over a specific period,using dynamic parameters like the net uptake rate constant for quantitative analysis.Dynamic imaging provides important complementary information to static imaging,offering more precise information for the diagnosis and treatment of lung cancer.This article focuses on the applications of dynamic imaging in the diagnosis of lung cancer,lymph node staging,evaluation of immunotherapy efficacy,and optimization of scanning protocols,providing a comprehensive review of the research progress of dynamic ^(18)F-FDG PET/CT imaging in the management of lung cancer.

关 键 词：肺肿瘤 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 发展趋势 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]