小胶质细胞调控对阿尔茨海默病病理影响的研究进展  

Recent advance in regulated effect of microglial on AD pathology

作　　者：张曼卿 兰宇飞 李磊 张欢 卢建锟 董耀远 高筱雅[2] 王晨阳 郭洪波[1] Zhang Manqing;Lan Yufei;Li Lei;Zhang Huan;Lu Jiankun;Dong Yaoyuan;Gao Xiaoya;Wang Chenyang;Guo Hongbo(National Key Clinical Specialty,Engineering Technology Research Center on Diagnosis and Treatment of Cerebrovascular Diseases in Ministry of Education,Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration,Neurosurgery Center,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;Department of Pediatric Neurology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;Department of Geriatrics,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)

机构地区：[1]南方医科大学珠江医院神经外科中心,国家临床重点专科,脑血管病诊断与治疗教育部工程研究中心,广东省普通高校脑功能修复与再生重点实验室,广州510282 [2]南方医科大学珠江医院小儿神经内科,广州510282 [3]南方医科大学珠江医院老年病科,广州510282

出　　处：《中华神经医学杂志》2025年第1期76-81,共6页Chinese Journal of Neuromedicine

基　　金：南方医科大学珠江医院院长基金(yzjj2023qn15);神经与肿瘤药物研发全国重点实验室开放课题重点项目。

摘　　要：小胶质细胞是大脑中的特化免疫细胞,通常负责清除脑部碎片和应对炎症。阿尔茨海默病(AD)的病理特征之一是脑内免疫系统的广泛激活,而小胶质细胞的动态变化和功能失调可成为推动AD进展的关键因素。本文对小胶质细胞在AD病理进程中的调控机制的研究进展进行综述,并总结其在AD治疗中的潜在价值,以期为探索AD的新治疗策略和干预靶点提供理论依据。Microglia are specialized immune cells in the brain,primarily responsible for clearing debris and responding to inflammation.One of the pathological features of Alzheimer's disease(AD)is the extensive activation of immune system in the brain,and the dynamic changes and dysfunction of microglia could become key factors for AD progression.This article reviews the research progress of regulated effect of microglial on AD pathology,and summarizes its potential value in AD treatment,in order to provide theoretical basis for exploring new therapeutic strategies and intervention targets for AD.

关 键 词：阿尔茨海默病 小胶质细胞 神经免疫 

分 类 号：R749.16[医药卫生—神经病学与精神病学]