LysoPC、Tau与GDF-10在口腔鳞状细胞癌中的表达水平及预后相关性分析  

Correlation Analysis of LysoPC,Tau,GDF-10 Levels and Prognosis in Oral Squamous Cell Carcinoma

作　　者：朱江[1] 宋冬惠[1] 杨学明 吴森斌[1] Zhu Jiang;Song Donghui;Yang Xueming(Department of Stomatology,Affiliated Hospital of Nantong University,Nantong 226001,China;Department of Stomatology,Zhenjiang First People's Hospital,Zhenjiang 212002,China)

机构地区：[1]江苏省南通大学附属医院口腔科,南通226001 [2]江苏省镇江市第一人民医院口腔科,镇江212002

出　　处：《华中科技大学学报(医学版)》2025年第1期90-94,共5页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：江苏省卫生健康委员会科研项目(No.Z2022080);江苏省南通市科技局科技计划项目(No.JCZ19112)。

摘　　要：目的 研究溶血磷脂酰胆碱(LysoPC)、微管相关蛋白Tau与生长分化因子-10(GDF-10)在口腔鳞状细胞癌中的表达水平及其与预后的相关性。方法 选取2017年4月至2019年4月于南通大学附属医院就诊的128例口腔鳞状细胞癌患者为研究组,并取同期100例口腔良性病变患者为对照组。比较2组患者LysoPC、Tau与GDF-10表达情况,分析口腔鳞状细胞癌患者LysoPC、Tau与GDF-10表达水平与临床分期、淋巴结转移、生存情况的关系,及其对预后的评估价值。结果 研究组病理组织中Tau与GDF-10表达阳性率、血清LysoPC表达水平均低于对照组(均P<0.05)。LysoPC、Tau与GDF-10低表达患者的Ⅲ~Ⅳ期、淋巴结转移占比高于高表达组(均P<0.05)。128例患者随访5年,生存86例(67.19%),死亡42例(32.81%)。LysoPC、Tau与GDF-10水平均与生存时间呈负相关(均P<0.05,r=-0.597、-0.622、-0.656)。Log-rank检验结果显示,LysoPC、Tau与GDF-10低表达者的5年生存率低于高表达者(均P<0.05)。LysoPC、Tau与GDF-10高表达是患者预后保护因素,淋巴结转移、高临床分期是预后危险因素(均P<0.05)。结论 LysoPC、Tau与GDF-10均在口腔鳞状细胞癌患者中低表达,其表达水平与临床分期、淋巴结转移存在相关性,其中低表达者具有更高的死亡风险。Objective To investigate the expression levels of lysophosphatidylcholine(LysoPC),microtubule associated protein Tau(MAPT)and growth differentiation factor-10(GDF-10)in oral squamous cell carcinoma(SCC),and their correlation with prognosis.Methods In all,128 patients with oral squamous cell carcinoma who visited Nantong University Affiliated Hospital from April 2017 to April 2019 were selected as the study group,and 100 patients with benign oral lesions during the same time period were selected as the control group.The expression levels of LysoPC,Tau and GDF-10 were compared between the 2 groups of patients.The relationship between the expression levels of LysoPC,Tau,GDF-10,the clinical staging,lymph node metastasis,and survival of oral squamous cell carcinoma patients were analyzed,and the assessment values of these factors for prognosis were evaluated.Results The positive rate of Tau and GDF-10 in pathological tissue and LysoPC in serum of the study group were lower than those of the control group(all P<0.05).Patients with low expression levels of LysoPC,Tau and GDF-10 had a higher proportion of stage Ⅲ to Ⅳ and lymph node metastasis than those with high expression levels of LysoPC,Tau and GDF-10(all P<0.05).The 128 patients were followed up for 5 years,86 survived(67.19%),42 died(32.81%).LysoPC,Tau and GDF-10 levels were negatively correlated with survival time(all P<0.05,r=-0.597,-0.622,-0.656).The results of log-rank test showed that the 5-year survival rate of LysoPC,Tau and GDF-10 low expression group was lower than that of LysoPC,Tau and GDF-10 high expression group(all P<0.05).The high expression levels of LysoPC,Tau and GDF-10 were protective factors,while lymph node metastasis and high clinical stage were risk factors(all P<0.05).Conclusion LysoPC,Tau and GDF-10 are all low expressed in patients with oral squamous cell carcinoma,and the expression level is correlated with clinical stage and lymph node metastasis.Low expression may indicate a higher risk of death.

关 键 词：溶血磷脂酰胆碱 微管相关蛋白Tau 生长分化因子-10 口腔鳞状细胞癌 预后 

分 类 号：R739.85[医药卫生—肿瘤]