ARID1A与PIK3CA突变在卵巢子宫内膜异位症恶变中的研究进展  

Research Progress of ARID1A and PIK3CA Mutations in Malignant Transformation of Ovarian Endometriosis

作　　者：张云凤 张宛玥 卢悦 王阳阳 井佳雨 牟婧祎 王悦(审校) ZHANG Yun-feng;ZHANG Wan-yue;LU Yue;WANG Yang-yang;JING Jia-yu;MU Jing-yi;WANG Yue(Department of Obstetrics and Gynecology,Zhengzhou University People′s Hospital,Henan Provincial People′s Hospital,Zhengzhou 450003,China;Department of Obstetrics and Gynecology,Henan University People′s Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院,河南省人民医院妇产科,450003 [2]河南大学人民医院妇产科

出　　处：《国际妇产科学杂志》2025年第1期19-22,共4页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(82072883);河南省重点研发专项(231111521100)。

摘　　要：子宫内膜异位症是一种常见的妇科疾病,育龄期女性的发病率为6%~10%。虽然子宫内膜异位症在形态学上呈良性表现,但易发生种植、侵袭及远处转移。卵巢子宫内膜异位症是最常见的子宫内膜异位症之一,治疗后易复发,严重威胁女性生殖健康。近年来大量研究发现,卵巢子宫内膜异位症具有恶变为卵巢癌的潜力。卵巢子宫内膜异位症恶变过程中最常见的是AT丰富结合域1A(AT-rich interaction domain 1A,ARID1A)与磷脂酰肌醇3激酶催化亚单位α(phosphatidylinositol 3-kinase catalytic subunit alpha,PIK3CA)基因突变,且发生在恶变早期。综述了ARID1A与PIK3CA突变在卵巢子宫内膜异位症恶变中的研究现状。Endometriosis(EMs)is a common gynecological disease with a prevalence of 6%to 10%in women of reproductive age.Although endometriosis is morphologically benign,it is susceptible to implantation,invasion and distant metastasis.Ovarian endometriosis is one of the most common forms of endometriosis,which is prone to recurrence after treatment and poses a serious threat to female reproductive health.In recent years,a large number of studies have found that ovarian endometriosis has the potential for malignant transformation into ovarian cancer.In the malignant transformation process of ovarian endometriosis,the most common mutations are in the ARID1A and PIK3CA genes,which occur in the early stage of malignancy.The current status of ARID1A and PIK3CA mutations in malignant transformation of ovarian endometriosis is reviewed.

关 键 词：子宫内膜异位症 卵巢肿瘤 基因 突变 ARID1A PIK3CA 

分 类 号：R711.71[医药卫生—妇产科学]