静电纺丝技术用于口腔癌的治疗研究进展  

The research progress of electrospinning technology in the treatment of oral cancer

作　　者：闫鑫 贾舟延 宗春琳(综述) 田磊 李德超(审校) YAN Xin;JIA Zhouyan;ZONG Chunlin;TIAN Lei;LI Dechao(School of Stomatology,Shandong second Medical University,China,261053 Weifang;School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology;State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Clinical Research Center for Oral Diseases,Maxillofacial Surgery,The Third Affiliated Hospital of Air Force Medical University,Xi'an;Qingdao Stomatological Hospital affiliated to Qingdao University)

机构地区：[1]山东第二医科大学口腔医学院,潍坊261053 [2]华中科技大学同济医学院药学院 [3]口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,空军军医大学第三附属医院颌面外科 [4]青岛大学附属青岛市口腔医院

出　　处：《实用口腔医学杂志》2025年第1期126-130,共5页Journal of Practical Stomatology

基　　金：青岛市医疗卫生重点学科建设项目(编号:2022-2024);青岛市口腔疾病临床医学研究中心(编号:22-3-7-lczx-7-nsh);山东省医药卫生口腔内科学重点学科(青岛大学附属青岛市口腔医院)项目号:(编号:2024-2026);青岛市科技惠民示范引导专项计划(编号:22-3-7-smjk-20-nsh)。

摘　　要：口腔癌(OC)是一种常见的恶性肿瘤,其发病率与死亡率逐年增长。据统计,每年全球新发病例超过五十万,其中大多数患者面临着治疗的挑战。静电纺丝技术(ES)是一种制备纳米纤维的方法,通过电场驱动使溶液中的聚合物形成纳米级别的纤维。自20世纪30年代被发现以来,得到广泛的关注和应用。文章就ES在OC治疗方面的应用研究进行综述。回顾ES的原理及工艺,阐述其在治疗OC中的应用研究,分析ES在OC治疗研究中面临的挑战,展望其未来的发展前景。Oral cancer(OC)is a common malignant tumor and its incidence and mortality rate is increasing year by year.According to statistics,there are over 500,000 new cases worldwide every year,and most patients face treatment challenges.Electrospinning technology(ES)is a method for preparing nanofibers by driving the polymer in solution to form nanoscale fibers through an electric field.Since its discovery in the 1930s,it has received widespread attention and application.This article reviews the application of ES in the treatment of OC.The principles and preparation process of ES are induced,its application research in treating OC is elaborated,and the challenges faced by ES in OC treatment research are analyzed.Finally,the future development is discussed.

关 键 词：静电纺丝 口腔癌 纳米载体 组织工程 生物功能 

分 类 号：R739.8[医药卫生—肿瘤]