质子超高剂量率(FLASH)放疗研究进展  

Research progress in proton ultra-high dose-rate(FLASH)radiotherapy

作　　者：左晓鑫 张安航 刘琦 朱健 Zuo Xiaoxin;Zhang Anhang;Liu Qi;Zhu Jian(Department of Radiation Physics and Technology,Cancer Hospital of Shandong First Medical University,Shandong Provincial Key Laboratory of Precision Radiotherapy for Pediatric Oncology in Medicine and Health,Jinan 250117,China)

机构地区：[1]山东第一医科大学附属肿瘤医院放射物理技术科,山东省医药卫生儿童肿瘤精确放疗重点实验室,济南250117

出　　处：《中华放射肿瘤学杂志》2025年第2期201-205,共5页Chinese Journal of Radiation Oncology

基　　金：国家自然科学基金面上项目(82172072);山东省自然科学基金项目(ZR2020LZL001);泰山学者青年专家项目(tsqn201909140)。

摘　　要：超高剂量率(FLASH)放疗作为放射治疗的新模式,能够在控制肿瘤的同时显著减少对周围正常组织的损伤。自2014年正式命名以来,FLASH放疗的研究不断增加,并且在2019年进入了指数级发展期。研究显示,电子、光子、质子均可诱发FLASH效应,而质子束能够克服入射深度浅、穿射剂量高的物理局限,被认为是最有效的解决方案。本文从细胞、动物、临床水平的研究,汇总FLASH质子治疗既往研究成果,归纳FLASH效应机制的假说,旨在为推进FLASH质子治疗研究和临床转化提供参考。Ultra-high dose-rate(FLASH)radiotherapy is a new mode of radiotherapy that can control tumors while significantly reducing damage to surrounding normal tissues.Since its official naming in 2014,FLASH radiotherapy research has continued to grow,and in 2019 it entered a period of exponential development.Studies have shown that electrons,photons,and protons can all induce the FLASH effect,but the proton beam can overcome the physical limitations of shallow incident depth and high penetration dose,which is considered to be the most effective solution.This article summarizes previous research results of FLASH proton therapy from the research at the cell,animal and clinical levels,and summarizes the hypothesis of the FLASH effect mechanism,aiming to provide reference for promoting the research and clinical transformation of FLASH proton therapy.

关 键 词：放射疗法 超高剂量率放射疗法 质子放射疗法 肿瘤控制 并发症 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]