脂质代谢在恶性肿瘤放射治疗中的作用研究进展  

Research progress in the role of lipid metabolism in radiotherapy for malignant tumors

作　　者：彭啟亮 沈云天[1] 朱雅群[1] 田野[1] Peng Qiliang;Shen Yuntian;Zhu Yaqun;Tian Ye(Department of Radiotherapy&Oncology,The Second Affiliated Hospital of Soochow University,Institute of Radiotherapy Oncology,Soochow University,Suzhou 215004,China)

机构地区：[1]苏州大学附属第二医院放疗科,苏州大学放射肿瘤学研究所,苏州215004

出　　处：《中华放射肿瘤学杂志》2025年第2期206-210,共5页Chinese Journal of Radiation Oncology

基　　金：国家自然科学基金(82003219);江苏省卫生健康委老年健康临床技术应用学科带头人项目(LR2021023);中核集团青年英才项目(彭啟亮)。

摘　　要：脂质代谢在恶性肿瘤的发生和发展中起着关键作用,对放射治疗的疗效有着重要影响。本文回顾了当前肿瘤放疗中脂质代谢作用的研究进展,关注了脂质代谢在肿瘤发生、发展和转移中的核心作用,以及放射治疗如何影响和调节脂质代谢。此外,本文重点探讨了脂质代谢与肿瘤放射敏感性之间的内在联系,同时综述了如何将脂质代谢作为一种治疗策略来提高放射治疗的疗效。深入研究肿瘤放射治疗中脂质代谢的作用,可为基于调节脂质代谢的肿瘤放射治疗的临床试验及机制研究提供帮助。Lipid metabolism plays a key role in tumorigenesis and progression and has a significant impact on the efficacy of radiotherapy.This article reviews the current research progress in the role of lipid metabolism in tumor radiotherapy,focusing on the central role of lipid metabolism in tumorigenesis,progression and metastasis,and how radiotherapy affects and regulates lipid metabolism.In addition,this article also investigates the intrinsic link between lipid metabolism and tumor radiosensitivity,and reviews how lipid metabolism can be used as a therapeutic strategy to improve the efficacy of radiotherapy.In-depth study of the role of lipid metabolism in tumor radiotherapy may offer assistance for clinical trials and mechanistic studies of tumor radiotherapy based on the modulation of lipid metabolism.

关 键 词：脂质代谢 肿瘤 恶性 放射疗法 放射敏感性 

分 类 号：R73[医药卫生—肿瘤]