原发性甲状腺淋巴瘤的诊治研究现状  

Current status of diagnosis and treatment of primary thyroid

作　　者：颜炜 Yan Wei(Deparment of Thyroid Surgery Afiliated Hospital of Guizhou Medical Universin,Guizhou,Guiyang,50001,China)

机构地区：[1]贵州医科大学附属医院,贵州贵阳550001

出　　处：《中国医学文摘(耳鼻咽喉科学)》2025年第1期165-169,共5页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：原发性甲状腺淋巴瘤(PTL,Primary thyroid lymphoma)是一种罕见的恶性肿瘤,约占所有甲状腺恶性肿瘤的5%,占所有结外淋巴瘤的3%,目前研究认为,PTL的发生机制与桥本甲状腺炎有关(HT,Hashimoto thyroiditis)。PTL临床表现通常为颈部增长的肿块,可引起颈部压迫的症状,小部分PLT临床表现出B细胞淋巴瘤的典型症状,包括体重减轻、发烧,夜间出汗。最常见的PTL是B细胞的非霍奇金淋巴瘤,主要是弥漫性大B细胞淋巴瘤(DLBC-L,Diffuselarge B-cell lymphoma),其次是黏膜相关淋巴组织淋巴瘤(MALT-L,Mucosa-associated lymphoid tissue lymphoma)或混合型(DLBC-L与MALT-L的结合),还有一些其他少见的类型,比如滤泡性淋巴瘤、小淋巴细胞性淋巴瘤、伯基特淋巴瘤、套细胞淋巴瘤等;而源自T细胞的淋巴瘤更加罕见。由于罕见,PTL尚未建立标准化的治疗方案。本文就PLT的诊治研究现状做一综述。Primary thyroid lymphoma(PTL)is a rare malignant tumor,accounting for about 5%of all thyroid malignant tumors,accounting for 3%of all extranodal lymphomas.The mechanism of PTL is related to Hashimoto thyroiditis(HT).The clinical presentation of PTL is usually a growing mass in the neck that can cause symptoms of neck compression.A small percentage of PTL patients present with typical symptoms of B-cell lymphoma,including weight loss and fever,and night sweating.The most common PTL is derived from B-cell non-Hodgkin's lymphoma,primarily Diffuse large B-cell lymphoma(DLBC-L),This is followed by mucosa-associated lymphoid tissue lymphoma(MALT-L)or mixed(DLBC-L and MALT-L),and a few other rare types,Such as follicular lymphoma,small lymphocytic lymphoma,Burkitt's lymphoma,mantle cell lymphoma,etc.T-cell lymphomas are even rarer.Due to its rarity,no standardized treatment has been established for PTL.This article reviews the research status of diagnosis and treatment of PTL.

关 键 词：甲状腺淋巴瘤 弥漫性大B细胞瘤 粘膜相关淋巴组织淋巴瘤 桥本甲状腺炎 

分 类 号：R73[医药卫生—肿瘤]