衰弱的研究进展:概念、危险因素、评估工具、机制及预防  

Research Progress on Frailty:Concept,Risk Factors,Assessment Tools,Mechanisms,and Prevention

作　　者：于尚辰 张文翠 张咸伟[1,2,3] YU Shangchen;ZHANG Wencui;ZHANG Xianwei(Department of Anesthesiology and Pain Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health,Wuhan 430030,China;Wuhan Clinical Research Center for Geriatric Anesthesia,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉学与疼痛医学科,武汉430030 [2]老年麻醉与围术期脑健康湖北省重点实验室,武汉430030 [3]武汉市老年麻醉临床医学研究中心,武汉430030

出　　处：《神经损伤与功能重建》2025年第2期119-124,共6页Neural Injury and Functional Reconstruction

摘　　要：衰弱是一种表现为机体生理系统储备能力下降的临床综合征,其发病率呈指数上升,严重影响老年人的生活质量和健康,甚至增加死亡风险。本文综述了衰弱的概念、危险因素、评估工具、可能的发生机制及预防的最新研究进展,指出了在识别、评估、干预和监测衰弱方面的挑战与未来方向。本文旨在帮助临床工作者对衰弱的概念、评估和预防有初步的理解,能从多方面对衰弱进行积极且综合的干预,尽可能延缓其发展,避免不良结果,提升老年人的生活质量。Frailty is a clinical syndrome characterized by a decline in the body’s physiological system reserve capacity.Its incidence is rising exponentially,seriously affecting the quality of life and health of the elderly,and even elevating the risk of mortality.This paper reviews the latest research progress on the concept,risk factors,assessment tools,possible mechanisms,and prevention of frailty,and highlights the challenges and future direc-tions in identifying,assessing,intervening,and monitoring frailty.This article aims to help clinicians initially un-derstand the concept,assessment,and prevention of frailty,so that they can actively and comprehensively inter-vene in frailty from multiple aspects,delay its development as much as possible,avoid adverse outcomes,and im-prove the quality of life of the elderly.

关 键 词：衰弱 危险因素 评估工具 发生机制 预防 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]