Acrylamide drives amidase-mediated gut dysbiosis to aggravate colitis  

丙烯酰胺驱动酰胺酶介导的肠道微生态失调加重结肠炎

作　　者：Daotong Li Yinghua Luo Huimin Fan Li Dong Xiaoying Zhang Yu Feng Meiling Tian Shuqing Zhang Wenjing Chen Lujia Zhang Jianwei Gao Xiangning Ma Xiaofei Wang Chen Ma Ruimao Zheng Xiaosong Hu Jinfeng Wang Fang Chen 李道通;罗颖华;樊洄敏;董丽;张小英;丰宇;田美玲;张淑晴;陈文静;张璐佳;高健玮;马湘宁;王小斐;马晨;郑瑞茂;胡小松;王金锋;陈芳

机构地区：[1]College of Food Science and Nutritional Engineering,National Engineering Research Center for Fruit and Vegetable Processing,Key Laboratory of Fruits and Vegetables Processing,Ministry of Agriculture,Engineering Research Centre for Fruits and Vegetables Processing,Ministry of Education,China Agricultural University,Beijing 100083,China [2]College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China [3]Department of Anatomy,Histology and Embryology,Health Science Center,Peking University,Beijing 100191,China

出　　处：《Science Bulletin》2025年第2期157-161,共5页科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(32230081,32371511,and 32001677)。

摘　　要：Inflammatory bowel diseases(IBDs)are chronic intestinal inflammatory disorders that have emerged as a global public health challenge[1].Increased availability and consumption of processed foods is considered as a crucial environmental factor underlying the worldwide prevalence of IBD[2].Nevertheless,how specific components in processed foods contribute to increased risk of IBD has not been clarified.Acrylamide(AA)is a ubiquitous food-related contaminant formed during thermal processing[3,4].

关 键 词：diseases prevalence clarified 

分 类 号：R57[医药卫生—消化系统]