前庭性偏头痛患者血清HMGB1、Hcy水平与疾病分期的关系研究  

Relationship between serum HMGB1,Hcy Levels and disease staging in patients with vestibular migraine

作　　者：李春鹏 傅俊 王雯 郑丽霞 范靓丰 袁闻 陈胜会[1] LI Chunpeng;FU Jun;WANG Wen;ZHENG Lixia;FAN Liangfeng;YUAN Wen;CHEN Shenghui(Department of Neurology,Shanghai Jiaotong University School of Medicine,Suzhou,Jiangsu 215028,China;Department of Pediatrics,Suzhou Jiulong Hospital,Shanghai Jiaotong University School of Medicine,Suzhou,Jiangsu 215028,China)

机构地区：[1]上海交通大学医学院苏州九龙医院神经内科,江苏苏州215028 [2]上海交通大学医学院苏州九龙医院儿科,江苏苏州215028

出　　处：《检验医学与临床》2025年第4期518-521,共4页Laboratory Medicine and Clinic

基　　金：上海交通大学医学院苏州九龙医院预研基金项目(SZJL202205)。

摘　　要：目的探讨前庭性偏头痛(VM)患者血清高迁移率族蛋白1(HMGB1)、同型半胱氨酸(Hcy)水平与疾病分期的关系。方法选取2020年3月至2023年3月该院收治的100例VM患者作为研究对象,按照疾病分期分为发作组48例和间歇组52例,另选择同期在该院体检健康的志愿者100例为对照组。采用酶联免疫吸附试验检测各组血清HMGB1、Hcy水平;采用受试者工作特征(ROC)曲线分析血清HMGB1、Hcy诊断VM患者疾病分期的价值;采用多因素Logistic回归分析VM患者疾病分期的影响因素。结果与对照组相比,间歇组和发作组血清HMGB1、Hcy水平明显升高(P<0.05);与间歇组相比,发作组血清HMGB1、Hcy水平明显升高(P<0.05)。血清HMGB1、Hcy联合检测诊断VM患者疾病分期的曲线下面积(AUC)大于HMGB1、Hcy单独诊断的AUC(Z=2.505、4.940,P=0.012、<0.001)。多因素Logistic回归分析结果显示,HMGB1、Hcy是VM患者疾病分期的影响因素(P<0.05)。结论VM患者血清HMGB1、Hcy呈高表达,与疾病分期具有一定的关系,有望成为诊断疾病分期的生物学标志物。Objective To investigate the relationship between serum high mobility group protein 1(HMGB1)and homocysteine(Hcy)levels and disease staging in patients with vestibular migraine(VM).Methods A total of 100 patients with VM treated at the hospital from March 2020 to March 2023 were selected as study subjects.According to disease staging,they were divided into the attack group(48 cases)and the interictal group(52 cases).Additionally,100 healthy volunteers who underwent physical examinations at the same hospital during the same period were selected as the control group.Serum HMGB1 and Hcy levels in each group were measured using enzyme-linked immunosorbent assay.Receiver operating characteristic(ROC)curve was used to analyze the value of serum HMGB1 and Hcy in the diagnosis of VM disease staging.Multivariate Logistic regression analysis was performed to identify factors influencing disease staging in VM patients.Results Compared with the control group,serum HMGB1 and Hcy levels were significantly elevated in both the interictal and attack groups(P<0.05).Furthermore,serum HMGB1 and Hcy levels in the attack group were significantly higher than those in the interictal group(P<0.05).The area under the curve(AUC)for the combined detection of serum HMGB1 and Hcy in the diagnosis of VM disease staging was greater than that for HMGB1 or Hcy alone(Z=2.505,4.940,P=0.012,<0.001).HMGB1 and Hcy were identified as influencing factors for disease staging in patients with VM(P<0.05).Conclusion Serum HMGB1 and Hcy levels are highly expressed in patients with VM and are both associated with disease staging.They show potential as biological markers for the differential diagnosis of disease stages.

关 键 词：前庭性偏头痛 高迁移率族蛋白1 同型半胱氨酸 疾病分期 诊断价值 

分 类 号：R747.2[医药卫生—神经病学与精神病学] R446.1[医药卫生—临床医学]