手性配位立体化学的创始、传承和发展  

Creation,Inheritance and Development of Chiral Coordination Stereochemistry

作　　者：方雪明[1] 陈雷奇 王宪营 丁冬冬 南子昂 张仕林 林丽榕[1] 章慧[1] Xueming Fang;Leiqi Chen;Xianying Wang;Dongdong Ding;Ziang Nan;Shilin Zhang;Lirong Lin;Hui Zhang(National Demonstration Center for Experimental Chemistry Education(Xiamen University),College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian Province,China)

机构地区：[1]厦门大学化学化工学院,化学国家级实验教学示范中心(厦门大学),福建厦门361005

出　　处：《大学化学》2025年第1期234-246,共13页University Chemistry

基　　金：厦门市自然科学基金青年项目(3502Z202371030);固体表面物理化学国家重点实验室开放课题(202426)。

摘　　要：2024年是我们在厦门大学化学系开展cis-[CoBr(NH_(3))(en)_(2)]Br_(2)的拆分和绝对不对称合成研究20周年,距配位化学创始人Alfred Werner于1911年成功拆分cis-[CoX(NH_(3))(en)_(2)]X_(2)(X=Br^(-)、Cl^(-))两个系列络合物已经113周年。为了纪念Werner及其团队对配位化学创始和发展的非凡贡献,本文首次通过详述cis-[CoX(NH_(3))(en)_(2)]X_(2)的拆分(Alfred Werner携Victor Louis King和Ernst Scholze)和cis-[CoBr(NH_(3))(en)_(2)]Br_(2)的绝对不对称合成(Kouichi Asakura)初创探究、后续进展以及相关研究,阐明手性八面体络合物的配位立体化学在科学发展史上的重要作用,并对cis-[CoBr(NH_(3))(en)_(2)]Br_(2)的绝对不对称合成提出基于配位化学基本原理的“电子转移催化-结晶诱导”机理。2024 marks the 20th anniversary of our research on the resolution and absolute asymmetric synthesis of cis-[CoBr(NH_(3))(en)_(2)]Br_(2) in the department of chemistry at Xiamen University.It has been 113 years since the founder of coordination chemistry,Alfred Werner,successfully resoluted the two series of complexes cis-[CoX(NH_(3))(en)_(2)]X_(2)(X=Br^(-),Cl^(-))in 1911.In order to commemorate Werner and his team’s extraordinary contributions to the founding and development of coordination chemistry,this article for the first time elaborates on the initial exploration,subsequent progress,and related studies on the resolution(Alfred Werner with Victor Louis King and Ernst Scholze)of cis-[CoX(NH_(3))(en)_(2)]X_(2) and the absolute asymmetric synthesis(Kouichi Asakura)of cis-[CoBr(NH_(3))(en)_(2)]Br_(2).It elucidates the important role of coordination stereochemistry of chiral octahedral complexes in the history of scientific development,and the“electron transfer catalysis-crystallization induction”mechanism based on the basic principles of coordination chemistry is proposed for the absolute asymmetric synthesis of cis-[CoBr(NH_(3))(en)_(2)]Br_(2).

关 键 词：配位化学 立体化学 八面体络合物 手性 拆分 绝对不对称合成 反应机理 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]