预后营养指数和营养控制状态评分对老年弥漫性大B细胞淋巴瘤患者预后的预测价值比较  

Comparison of Prognostic Value of Prognostic Nutritional Index and Nutritional Control Status Scores in Elderly Patients with Diffuse Large B-Cell Lymphoma

作　　者：曹丛丛 王鑫鑫 CAO Congcong;WANG Xinxin(Department of Hematology,Pingyi County People's Hospital,Linyi 273300,China)

机构地区：[1]平邑县人民医院血液内科,山东临沂273300

出　　处：《反射疗法与康复医学》2024年第22期145-148,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的分析预后营养指数(PNI)和营养控制状态(CONUT)评分对老年弥漫性大B细胞淋巴瘤(DLBCL)患者预后的预测价值。方法回顾性选取2021年3月—2023年12月平邑县人民医院收治的86例老年DLBCL患者临床资料,根据患者预后情况将其分为复发组(n=21)与非复发组(n=65)。比较两组患者的PNI、CONUT评分,采用Logistic回归分析影响老年CONUT患者预后的危险因素,采用受试者工作特征(ROC)曲线评估PNI、CONUT评分对老年DLBCL患者预后的预测价值。结果两组临床分期、B症状、PNI、CONUT评分指标比较,组间差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,临床分期、PNI、CONUT评分是影响DLBCL预后的危险因素(P<0.05)。ROC曲线分析PNI预测DLBCL预后的曲线下面积(AUC)为0.677(95%CI:0.542~0.812),灵敏度为52.4%,特异度为78.5%,约登指数为0.309;CONUT评分预测DLBCL预后的AUC为0.882(95%CI:0.774~0.990),灵敏度为81.0%,特异度为86.2%,约登指数为0.672,CONUT评分预测价值较大,AUC、灵敏度、特异度、约登指数均高于PNI。结论临床分期、PNI、CONUT评分是影响DLBCL预后的危险因素,PNI、CONUT评分对老年DLBCL患者预后具有较高的预测价值,CONUT评分预测价值高于PNI。Objective The prognostic nutritional index(PNI)and nutritional control status(CONUT)scores were used to predict the prognosis of elderly patients with diffuse large B-cell lymphoma(DLBCL).Methods Clinical data of 86 elderly DLBCL patients admitted to Pingyi County People's Hospital from March 2021 to December 2023 were retrospectively selected,and the patients were divided into a relapsed group(n=21)and a non-relapsed group(n=65)according to their prognosis.The PNI and CONUT scores of the two groups were compared,the risk factors affecting the prognosis of elderly patients with CONUT were analyzed by Logistic regression,and the predictive value of PNI and CONUT scores on the prognosis of elderly patients with DLBCL was evaluated by receiver operating characteristic(ROC)curve.Results There were significant differences in clinical stage,B symptom,PNI and CONUT scores between the two groups(P<0.05).Multivariate Logistic regression analysis showed that clinical stage,PNI and CONUT scores were the risk factors affecting the prognosis of DLBCL(P<0.05).ROC curve analysis predicted the prognosis of DLBCL by PNI with an area under the curve(AUC)of 0.677(95%CI:0.542~0.812),sensitivity of 52.4%,specificity of 78.5%and Yoden index of 0.309.The AUC of CONUT score in predicting the prognosis of DLBCL was 0.882(95%CI:0.774~0.990),the sensitivity was 81.0%,the specificity was 86.2%,and the Yoden index was 0.672,CONUT score had greater predictive value,and AUC,sensitivity,specificity,and Yoden index were all higher than PNI.Conclusion Clinical stage,PNI and CONUT score are risk factors affecting the prognosis of DLBCL. PNI and CONUT score have high predictive value for the prognosis of elderly DLBCL patients, and CONUT score has higher predictive value than PNI.

关 键 词：老年 弥漫性大B细胞淋巴瘤 预后营养指数 营养控制状态评分 预后 预测价值 

分 类 号：R733[医药卫生—肿瘤]