AGGF1基因与人类肿瘤之间的泛癌分析  

Analysis of pan-cancer between AGGF1 gene and human tumor

作　　者：车逸宁 甄思斌 王晓 赵燕 李冕 CHE Yining;ZHEN Sibin;WANG Xiao;ZHAO Yan;LI Mian(School of Biomedical Sciences,Shandong First Medical University,Shandong,Jinan 250000,China)

机构地区：[1]山东第一医科大学生物医学科学学院,山东济南250000

出　　处：《中国医药科学》2025年第2期4-7,共4页China Medicine And Pharmacy

基　　金：山东省重点研发计划(重大科技创新工程)(2021ZDSYS27)。

摘　　要：目的通过生物信息学方法进行血管生长因子(AGGF1)基因与人类肿瘤之间的泛癌分析,探究AGGF1的表达与不同癌症临床预后的关系及其分子作用机制。方法利用癌症基因组图谱(TCGA)和基因型-组织表达(GTEx)等数据库的数据和基因的表达、改变等分子特征,对多种肿瘤的AGGF1基因进行全面检测。结果AGGF1在肝癌、胆管癌、弥漫性大B细胞淋巴瘤和胸腺癌组织中显著高表达,在肾透明细胞癌、甲状腺癌和肾嫌色细胞癌组织中显著降低(P<0.05)。AGGF1的高表达与膀胱尿路上皮癌、宫颈鳞癌和腺癌、肾嫌色细胞癌、脑低级别胶质瘤的预后不良有关,其低表达与肾透明细胞癌的预后不良有关(P<0.05)。结论根据AGGF1基因与人类肿瘤之间的泛癌分析及相关文献查询,AGGF1可能是肝细胞肝癌的潜在治疗靶点,并且可能与血管内皮生长因子合作,参与胃癌的肿瘤血管生成,AGGF1蛋白阳性表达与乳腺癌患者的预后相关并且AGGF1基因可能参与结直肠癌细胞迁移和侵袭。Objective To analyze the pan-cancer between angiogenic factor with G patch and FHA domains 1(AGGF1)gene and human tumor by bioinformatics method,and to explore the relationship between the expression of AGGF1 and the clinical prognosis of different cancers and its molecular mechanism.Methods Comprehensive detection of AGGF1 gene in various tumors was conducted using data from databases such as the cancer genome atlas(TCGA)and Genotype-Tissue Expression(GTEx),as well as molecular characteristics such as gene expression and changes.Results AGGF1 was highly expressed in hepatocellular carcinoma,cholangiocarcinoma,diffuse large B-cell lymphoma and thoracic adenocarcinoma,but significantly decreased in renal clear cell carcinoma,thyroid carcinoma and renal chromophobe cell carcinoma(P<0.05).The high expression of AGGF1 is related to the poor prognosis of bladder urothelial carcinoma,cervical squamous cell carcinoma and adenocarcinoma,renal chromophobe cell carcinoma and low-grade glioma,and its low expression is related to the poor prognosis of renal clear cell carcinoma(P<0.05).Conclusion According to the pan-cancer analysis between AGGF1 gene and human tumor and related literature search,AGGF1 may be a potential therapeutic target for hepatocellular carcinoma,and may cooperate with vascular endothelial growth factor to participate in tumor angiogenesis of gastric cancer.The positive expression of AGGF1 protein is related to the prognosis of breast cancer patients,and AGGF1 gene may participate in the migration and invasion of colorectal cancer cells.

关 键 词：AGGF1 VG5Q 肿瘤 预后 生物信息学 

分 类 号：R730.2[医药卫生—肿瘤]