基于Web of Science对2004—2023年神经病理性疼痛研究的知识图谱分析  

Knowledge map analysis of neuropathic pain research from 2004 to 2023 based on Web of Science

作　　者：钟冠杰 李峰[2] ZHONG Guanjie;LI Feng(College of Acupuncture and Moxibustion and Orthopaedics,Hubei University of Chinese Medicine,Hubei,Wuhan 430065,China;Department of Orthopedics,Guanggu Branch,Hospital of Traditional Chinese Medicine in Hubei Province Affiliated to Hubei University of Chinese Medicine,Hubei,Wuhan 430074,China)

机构地区：[1]湖北中医药大学针灸骨伤学院,湖北武汉430065 [2]湖北中医药大学附属湖北省中医院光谷院区骨伤科,湖北武汉430074

出　　处：《中国医药科学》2025年第2期84-87,共4页China Medicine And Pharmacy

基　　金：湖北省自然科学基金计划项目(2023AFD131)。

摘　　要：目的神经病理性疼痛(NPP)的信号通路机制是一个广泛受关注的领域,本研究为该领域的热点和发展趋势提供信息。方法基于Web of Science数据库,利用CiteSpace分析软件生成知识图谱,检索日期为2004年1月1日至2023年6月30日。结果中国和美国发表的文章占比位居前列,分别占43.85%和18.15%。文章发表位居前2位的机构是中山大学和浙江中医药大学。国家之间的合作有一定的地域性,作者团队间彼此存在一定的合作,但以疏散团队为主。关键词分析表明过去老鼠实验是研究热门,而蛋白质和星形胶质细胞成为新热点。结论NPP领域中信号通路的深化研究是主流的趋势,而小胶质细胞是神经病理性疼痛主要的研究方向,干细胞疗法和间充质干细胞衍生的细胞外载体/外泌体为潜在治疗手段。Objective To provide information for the hotspots and development trends in the widespread concerned field of signal pathway mechanism of neuropathic pain(NPP).Methods Based on the Web of Science database,the knowledge map was generated by CiteSpace analysis software,and the retrieval date was from January 1,2004 to June 30,2023.Results Articles published by China and the United States accounted for 43.85%and 18.15%respectively.The top two institutions for publishing articles were Sun Yat-sen University and Zhejiang Chinese Medical University.The cooperation between countries was regional,and there was some cooperation between the author teams,but mainly scattered teams.Keyword analysis showed that mouse experiments were hotspots in the past,while protein and astrocytes became new hot topics.Conclusion The deepening research of signal pathway in NPP field is the mainstream trend,and microglia is the main research direction of neuropathic pain,and stem cell therapy and extracellular vesicles/exosomes derived from mesenchymal stem cells are potential treatment methods.

关 键 词：研究热点 信号通路 研究前沿 知识图谱 信息可视化 CiteSpace 

分 类 号：R741[医药卫生—神经病学与精神病学]