医务工作者结直肠癌筛查问卷与粪便SDC2基因甲基化联合筛查对结肠镜依从性的影响分析  

Analysis of the impact of combined screening of colorectal cancer questionnaire and fecal SDC2 gene methylation by medical workers on colonoscopy compliance

作　　者：陆美吉 程伟[2] 郭晓晨 杨怀中[2] 戴宁 纪峰 顾知恩 杨宇飞[2] LU Meiji;CHENG Wei;GUO Xiaochen;YANG Huaizhong;DAI Ning;JI Feng;GU Zhien;YANG Yufei(Graduate School of Beijing University of Chinese Medicine(Xiyuan Clinical School),Beijing 100029,China;Department of Oncology,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]北京中医药大学研究生院(西苑临床学院),北京100029 [2]中国中医科学院西苑医院肿瘤科,北京100091

出　　处：《中国医药科学》2025年第2期142-145,共4页China Medicine And Pharmacy

基　　金：中国中医科学院西苑医院-中医药临床科研一体化平台建设专项(XYZX0404-02)。

摘　　要：目的研究结直肠癌高危人群筛查问卷与硫酸类肝素蛋白多糖(SDC2)基因甲基化检测联合筛查对医务工作者结肠镜依从性的影响及其相关因素。方法2021年1月至2022年12月以中国中医科学院西苑医院医务工作者作为研究对象,收集结直肠癌高危人群筛查问卷和SDC2基因甲基化试剂盒结果,评定高危人群并提醒进行肠镜检查,分析肠镜依从性以及影响因素。结果本研究共纳入771人并全部完成结直肠癌高危人群筛查问卷,其中604人接受SDC2基因甲基化检测,联合筛查后高危人群中肠镜依从性为22.91%,经多因素分析后,联合筛查高危人群中肠镜依从性与SDC2基因甲基化检测高危有关(OR=174.167,P<0.001)。结论联合筛查肠镜依从性较低,医务工作者对于结直肠癌筛查缺乏重视,单独使用SDC2基因甲基化检测能有效提高肠镜依从性。Objective To investigate the combined screening of colorectal cancer high-risk population screening questionnaire and heparan sulphate proteoglycans(syndecan-2,SDC2)gene methylation detection on the compliance of medical workers with colonoscopy and its related factors.Methods From January 2021 to December 2022,medical workers at Xiyuan Hospital of China Academy of Chinese Medical Sciences were selected as the study subjects.Screening questionnaires and SDC2 gene methylation test kits were collected from high-risk populations for colorectal cancer,and high-risk populations were assessed and reminded to undergo colonoscopy.Colonoscopy compliance and influencing factors were analyzed.Results A total of 771 individuals were included in this study and all completed the screening questionnaire for high-risk populations of colorectal cancer.Among them,604 individuals underwent SDC2 gene methylation testing.After combined screening,the compliance rate of colonoscopy in high-risk populations was 22.91%.After multiple factor analysis,it was found that colonoscopy compliance in high-risk populations was associated with high risk of SDC2 gene methylation testing(OR=174.167,P<0.001).Conclusion The combined screening colonoscopy compliance is low and medical workers lack attention to colorectal cancer screening.The use of SDC2 gene methylation testing alone can effectively improve colonoscopy compliance.

关 键 词：结直肠癌 筛查 医务工作者 SDC2基因甲基化 结肠镜依从性 

分 类 号：R73-31[医药卫生—肿瘤] R735.3[医药卫生—临床医学]