Effects of probiotics,prebiotics and synbiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus:a GRADE-assessed systematic review and meta-analysis of randomized controlled trials  

作　　者：Yanyan Tian Jiayue Xia Lihua Li Ligang Yang Hua Xiao Guoping Gao Yuanyuan Wang Chen Zhang Tiange Bu Guiju Sun 

机构地区：[1]Key Laboratory of Environmental Medicine and Engineering of Ministry of Education,Department of Nutrition and Food Hygiene,School of Public Health,Southeast University,Nanjing 210009,China [2]Lianshui People’s Hospital Affi liated to Kangda College of Nanjing Medical University,Huai’an 223400,China [3]Gong’an County People’s Hospital,Jingzhou 434300,China [4]Department of Nutritional Sciences,University of Toronto,Toronto M5S 1A1,Canada

出　　处：《Food Science and Human Wellness》2025年第1期29-49,共21页食品科学与人类健康(英文)

基　　金：Jiangsu College of Nursing 2023 Special Fund for Research and Development of Medical-Educational Integration。

摘　　要：A systematic review and meta-analysis study was conducted to assess the effectiveness of probiotic/prebiotic/synbiotic supplementation on the effects of cardiovascular risk factors in patients with type 2 diabetes mellitus(T2DM)based on data from randomized controlled trials(RCTs).We searched electronic databases including PubMed,Cochrane Library,Embase,and Web of Science to identify clinical trials published up to 31 March 2023.Data was pooled using a random-effects model if significant heterogeneity(I2>50%),otherwise use a fixed-effects model.Fifty-six trials that included 3317 patients were enrolled for analysis.Meta-analysis reported that probiotic/prebiotic/synbiotic supplementation significantly reduced systolic blood pressure(SBP)(weighted mean difference(WMD):-3.57 mmHg,95% confidence interval(CI):-5.36,-1.78;P=0.000),diastolic blood pressure(DBP)(WMD:-2.05 mmHg,95%CI:-3.07,-1.04;P=0.000),triglycerides(TG)(WMD:-16.10 mg/dL,95%CI:-20.16,-12.05;P=0.000),total cholesterol(TC)(WMD:-14.00 mg/dL,95%CI:-20.46,-7.55;P=0.000),low-density lipoprotein cholesterol(LDL-C)(WMD:-7.03 mg/dL,95%CI:-9.25,-4.81;P=0.000),fasting plasma glucose(FPG)(WMD:-16.57 mg/dL,95%CI:-20.39,-12.74;P=0.000),hemoglobin A1c(HbA1c)(WMD:-0.44%,95%CI:-0.68,-0.20;P=0.000),insulin(standardized mean difference(SMD):-0.37,95%CI:-0.53,-0.21;P=0.000),homeostatic model assessment of insulin resistance(HOMA-IR)(WMD:-1.05,95%CI:-1.56,-0.54;P=0.000),C-reactive protein(CRP)(SMD:-0.35,95%CI:-0.57,-0.13;P=0.002),tumor necrosis factor-α(TNF-α)(SMD:-1.07,95%CI:-1.57,-0.56;P=0.000),interleukin-6(IL-6)(SMD:-0.37,95%CI:-0.61,-0.13;P=0.003)levels,they also increased the high-density lipoprotein cholesterol(HDL-C)(WMD:3.70 mg/dL,95%CI:1.80,5.60;P=0.000)levels in T2DM patients,as compared to the placebo groups.This meta-analysis supports the use of probiotic/prebiotic/synbiotic supplementation as an adjunctive therapy to improve blood pressure,glycemic control parameters,lipid profile and inflammatory markers in patients with T2DM,which are well-known cardiovasc

关 键 词：Probiotic Prebiotic SYNBIOTIC Type 2 diabetes mellitus Cardiovascular risk factors Systematic review and meta-analysis 

分 类 号：R587.1[医药卫生—内分泌] R459.3[医药卫生—内科学]