Mitochondria-targeted nanoparticles for encapsulating astaxanthin:exploring the reason for alleviating oxidative damage  

作　　者：Yannan Chen Siyuan Fei Lijuan Zhang Mingqian Tan 

机构地区：[1]Academy of Food Interdisciplinary Science,School of Food Science and Technology,Dalian Polytechnic University,Dalian 116034,China [2]National Engineering Research Center of Seafood,Dalian Polytechnic University,Dalian 116034,China [3]Collaborative Innovation Center of Seafood Deep Processing,Dalian Polytechnic University,Dalian 116034,China

出　　处：《Food Science and Human Wellness》2025年第1期124-133,共10页食品科学与人类健康(英文)

基　　金：supported by the National Science Fund for Distinguished Young Scholars of China(31925031);Mount Tai Industrial Blue Talent Program of Shandong Province(tsls20231209)。

摘　　要：Oxidative stress is considered as a critical factor in the process of pathological diseases,and mitochondria are considered as vital target organelles for disease intervention.The purpose of this study was aimed to evaluate the antioxidant efficacy of mitochondria-targeted astaxanthin nanoparticle on hydrogen peroxideinduced oxidative damage.As expected,mitochondria-targeted nanoparticle showed excellent mitochondria co-localization ability with higher Pearson's correlation coefficient(r=0.88).In vitro experiments suggested that the mitochondria-targeted astaxanthin nanoparticle could promote cell viability and increase antioxidantrelated enzyme activities.Simultaneously,metabolomics analysis indicated that mitochondria-targeted astaxanthin nanoparticle could alleviate oxidative stress by regulating amino acid metabolism and energy metabolism.Altogether,all these results strongly confirmed the mitochondria-targeted strategy for astaxanthin delivery could relieve oxidative stress and had great promise in the application of disease intervention.

关 键 词：Oxidative stress Mitochondria-targeted ASTAXANTHIN Antioxidant Metabolism 

分 类 号：TS201.4[轻工技术与工程—食品科学]