阿尔茨海默病患者大脑皮层厚度与β淀粉样蛋白病理性沉积的相关性  

Correlation between cortical thickness and pathological deposition ofβ-amyloid in patients with Alzheimer disease

作　　者：朱侣明 侯军文 钟志民[1] 葛璟洁[2] 吴越 陈圣文[1] 罗建华[1] 杨贇豪 王静[2] 林华媚 左传涛[2] 管一晖[2] ZHU Lyuming;HOU Junwen;ZHONG Zhimin;GE Jingjie;WU Yue;CHEN Shengwen;LUO Jianhua;YANG Yunhao;WANG Jing;LIN Huamei;ZUO Chuantao;GUAN Yihui(Department of Medical Imaging,Xingguo People's Hospital,Xingguo Hospital Affiliated to Gannan Medical University,Ganzhou,342400,China;Department of Nuclear Medicine/PET Center,Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Radiology,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]兴国县人民医院赣南医科大学附属兴国医院医学影像科,江西赣州342400 [2]复旦大学附属华山医院核医学/PET中心,上海200040 [3]复旦大学附属华山医院放射科,上海200040

出　　处：《中国医学影像技术》2025年第2期207-211,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察阿尔茨海默病(AD)源性轻度认知障碍(MCI)及痴呆患者大脑皮层厚度与β淀粉样蛋白(Aβ)病理性沉积的相关性。方法前瞻性纳入22例AD,根据认知障碍程度将其分为痴呆组(n=12)及MCI组(n=10);同时招募17名无认知功能障碍的健康人作为对照组。行MR检查和18 F-贝他苯(18 F-FBB)PET显像,计算大脑皮层厚度和Aβ沉积值[即Centiloid(CL)值]并进行3组间及两两组间比较,分析其相关性。结果痴呆组、MCI组及对照组大脑皮层厚度分别为(2.18±0.14)、(2.35±0.08)及(2.36±0.09)mm,3组间差异有统计学意义(P<0.05);其中,痴呆组大脑皮层厚度显著低于MCI组及对照组(P均<0.05)。痴呆组、MCI组及对照组CL值分别为77.97(63.07,95.55)、65.51(54.54,90.50)及-1.17(-9.66,4.88),3组间差异有统计学意义(P<0.05);其中,痴呆组及MCI组均显著大于对照组(P均<0.05)。MCI组大脑皮层厚度与CL值呈中度负相关(r=-0.580,P=0.048),而在其余2组二者无显著相关(P均>0.05)。结论AD源性MCI患者大脑皮层厚度与Aβ异常沉积呈中度负相关,而在痴呆期二者无明显相关。Objective To observe the correlation between cortical thickness and pathological deposition ofβ-amyloid(Aβ)in patients with Alzheimer disease(AD)induced mild cognitive impairment(MCI)or dementia.Methods Totally 22 AD patients were prospectively enrolled and divided into dementia group(n=12)and MCI group(n=10)based on the degree of cognitive impairment,while 17 healthy individuals without cognitive impairment were recruited as control group.MR examination and 18 F-florbutaben(18 F-FBB)PET imaging were performed,the cortical thickness and Aβdeposition value(Centiloid[CL]value)were calculated and compared among 3 groups and between each 2 groups,then the correlation between the above two indexes was analyzed.Results The cortical thickness in dementia group,MCI group and control group was(2.18±0.14),(2.35±0.08)and(2.36±0.09)mm,respectively,with significant difference among 3 groups(P<0.05).The cortical thickness in dementia group was significantly thinner than that in MCI group and control group(both P<0.05).CL value in dementia group,MCI group and control group was 77.97(63.07,95.55),65.51(54.54,90.50)and-1.17(-9.66,4.88),respectively,with significant difference among 3 groups(P<0.05).CL value in dementia group and MCI group were significantly higher than in control group(both P<0.05).The cortical thickness was moderately negatively correlated with CL value in MCI group(r=-0.580,P=0.048)but not in the other 2 groups(both P>0.05).Conclusion The cortical thickness was moderately negatively correlated with abnormal deposition of Aβin patients with AD induced MCI,but was not during dementia.

关 键 词：阿尔茨海默病 认知障碍 大脑皮质 淀粉样物质 磁共振成像 正电子发射断层显像 

分 类 号：R742[医药卫生—神经病学与精神病学] R445[医药卫生—临床医学]