酒精使用障碍患者早期脑微结构改变与认知功能的相关性  

Correlations of early brain microstructural changes and cognitive function in patients with alcohol use disorder

作　　者：闫一锦 王晨阳 高燕 刘宴池 董家文 李杰[1] 赵洪增[1] YAN Yijin;WANG Chenyang;GAO Yan;LIU Yanchi;DONG Jiawen;LI Jie;ZHAO Hongzeng(Department of Interventional Radiology,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,China;Department of Diagnostic Radiology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Department of Imaging,the Eighth People's Hospital of Zhengzhou,Zhengzhou 450018,China)

机构地区：[1]新乡医学院第二附属医院放射介入科,河南新乡453002 [2]中国人民解放军总医院第一医学中心放射诊断科,北京100853 [3]郑州市第八人民医院影像科,河南郑州450018

出　　处：《中国医学影像技术》2025年第2期224-228,共5页Chinese Journal of Medical Imaging Technology

基　　金：新乡市科技攻关计划(GG2020036);河南省精神心理疾病临床医学研究中心开放课题(2020-zxkfkt-001)。

摘　　要：目的观察酒精使用障碍(AUD)患者早期脑微结构改变及其与认知功能的相关性。方法回顾性选取81例AUD患者(AUD组)及75名健康志愿者(对照组),以基于体素形态学分析和基于表面形态学分析方法测量脑区灰质体积(GMV)及皮层厚度,分析组间存在差异脑区上述参数与临床认知功能量表评分的相关性。结果相比对照组,AUD组双侧海马、岛叶、顶下缘角回、直回、中央后回和小脑角1区,左内侧额上回、楔前叶、前扣带皮层、颞中回和枕中回,以及右侧舌回GMV显著下降;双侧额上回、额中回、额下回、缘上回、顶上小叶、顶下小叶、中央后回、中央前回、颞上回及颞中回皮层厚度均减小。AUD组左侧内侧额上回GMV与匹兹堡睡眠质量指数评分呈正相关(r=0.301,P=0.006),左、右侧直回GMV均与霍普金斯词语学习测验修订版评分呈正相关(r=0.328、0.326,P均=0.003)、与连线测试B评分呈负相关(r=-0.295、-0.312,P=0.008、0.005);左侧中央前回及右侧额中回下部皮层厚度均与贝克焦虑量表评分呈正相关(r=0.323、0.289,P=0.003、0.009)。结论AUD患者早期存在前额叶皮层萎缩,且与认知功能受损相关。Objective To explore the early brain microstructural changes in patients with alcohol use disorder(AUD)and the correlations with cognitive function.Methods Totally 81 AUD patients(AUD group)and 75 healthy volunteers(control group)were retrospectively enrolled.Gray matter volume(GMV)and cortical thickness of brain regions were calculated with voxel-based morphometry and surface-based morphometry,and the correlations of the above indexes of brain regions being significantly different between groups and clinical cognitive function scale scores were analyzed.Results In AUD group,GMV of bilateral hippocampus,insula,inferior parietal angular gyrus,straight gyrus,central posterior gyrus and cerebellar angle 1 area,of left medial superior frontal gyrus,precuneus,anterior cingulated cortex,middle temporal gyrus and middle occipital gyrus,as well as of right lingual gyrus reduced significantly compared with those in control group.The cortical thickness of bilateral superior frontal gyrus,middle frontal gyrus,inferior frontal gyrus,supramarginal gyrus,superior parietal lobule,inferior parietal lobule,central posterior gyrus,central anterior gyrus,temporal superior gyrus and middle temporal gyrus reduced in AUD group.In AUD group,GMV of left medial superior frontal gyrus was positively correlated with Pittsburgh sleep quality index score(r=0.301,P=0.006),while of the left and right straight gyrus were positively correlated with Hopkins verbal learning test-revised score(r=0.328,0.326;both P=0.003)but negatively correlated with trail making test-B score(r=-0.295,-0.312;P=0.008,0.005),while the cortical thickness of the left central anterior gyrus and the lower part of the right middle frontal gyrus were positively correlated with Beck anxiety inventory score(r=0.323,0.289;P=0.003,0.009).Conclusion Prefrontal cortex atrophy could be observed in early stage AUD patients,which was correlated with cognitive function impaired.

关 键 词：酒精相关性障碍 大脑皮质 磁共振成像 

分 类 号：R749.62[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]