经COG-TB与FUS-TB对有CsPCa检出及根治术后ISUP分级的影响  

Effect transperineal cognitive registration target biopsy versus software-based fusion target biopsy on the detection rate of clinically significant prostate cancer and ISUP grading after radical prostatectomy

作　　者：尤俊杰 潘永昇 沈城 陈站 潘晓东[1] 刘振民 张勇 郑兵[1] You Junjie;Pan Yongsheng;Shen Cheng;Chen Zhan;Pan Xiaodong;Liu Zhenmin;Zhang Yong;Zheng Bing(Department of Urology,the Second Affiliated Hospital of Nantong University,Nantong 226000,China)

机构地区：[1]南通大学第二附属医院泌尿外科,南通226000

出　　处：《国际泌尿系统杂志》2025年第1期53-57,共5页International Journal of Urology and Nephrology

基　　金：江苏省老年健康科研课题(LKM20222059)。

摘　　要：目的探究会阴认知融合活检(COG-TB)与软件融合活检(FUS-TB)对有临床意义前列腺癌(CsPCa)检出及根治术后国际泌尿病理协会(ISUP)分级的影响。方法回顾性分析2022年8月至2023年12月于本院行前列腺活检并行根治术治疗的143例患者的临床资料,将其中68例行COG-TB患者作为COG组,75例行FUS-TB患者作为FUS组。收集两组患者的一般资料,包括年龄、体质量指数(BMI)、前列腺特异性抗原(PSA)、前列腺体积、PI-RADS评分;比较两组患者的前列腺癌和CsPCa检出率;比较两组中不同PSA水平和PI-RADS评分患者的前列腺癌和CsPCa检出率;比较两组患者前列腺癌根治术后的ISUP分级情况。结果两组患者的年龄、BMI、前列腺体积、PSA、PI-RADS评分比较,差异均无统计学意义(均P>0.05)。COG组患者的前列腺癌和CsPCa检出率略高于FUS组,但差异无统计学意义(P>0.05)。对于不同的PSA分层患者,COG组中10 ng/mL≤PSA<20 ng/mL患者的前列腺癌检出率更高(P<0.05)。对于不同的PI-RADS评分患者,COG组中PI-RADS评分为4分患者的CsPCa检出率更高(P<0.05)。COG组中术后ISUP分级出现升级的患者人数少于FUS组,但差异无统计学意义(P>0.05)。结论在10≤PSA<20 ng/mL患者中COG-TB对前列腺癌的检出率更高,在PI-RADS评分为4分的患者中COG-TB对CsPCa的检出率更高。前列腺癌根治术后FUS组患者出现ISUP升级的患者较多,但无统计学差异。Objective To investigate the effect transperineal cognitive registration target biopsy(COG-TB)versus software-based fusion target biopsy(FUS-TB)on the detection rate of clinically significant prostate cancer(CsPCa)and International Society of Urological Pathology(ISUP)grading after radical prostatectomy.Methods A retrospective analysis was performed on 143 patients who underwent prostate biopsy and radical operation in our hospital from August 2022 to December 2023.Among them,68 COG-TB patients were selected as the COG group and 75 FUS-TB patients as the FUS group.General data,including age,body mass index(BMI),prostate-specific antigen(PSA),prostate volume,and PI-RADS score,were collected in both groups.The detection rates of prostate cancer and CsPCa were compared between the two groups.Prostate cancer and CsPCa detection rates were comparedbetween the two groups in patients with different PSA levels and PI-RADS scores.The ISUP grades of the two groups were compared after radical resection of prostate cancer.Results There were no significant differences in age,BMI,prostate volume,PSA and PI-RADS scores between 2 groups(all P>0.05).The detection rates of prostate cancer and CsPCa in COG group were slightly higher than those in FUS group,but the difference was not statistically significant(P>0.05).For different PSA stratification,the prostate cancer detection rate of patients with 10 ng/mL≤PSA<20 ng/mL in COG group was significantly higher(P<0.05).For different PI-RADS scores,the CsPCa detection rate of patients with PI-RADS score of 4 in COG group was significantly higher(P<0.05).The number of patients with upgraded ISUP grade in COG group was less than that in FUS group,but the difference was not statistically significant(P>0.05).Conclusions The detection rate of COG-TB for prostate cancer is higher in patients with 10≤PSA<20 ng/mL,and the detection rate of COG-TB for CsPCa is higher in patients with PI-RADS score of 4.There are more patients in the FUS group with ISUP escalation after radical prostate canc

关 键 词：前列腺肿瘤 会阴 活组织检查 针吸 磁共振成像 

分 类 号：R73[医药卫生—肿瘤]