子宫内膜癌分子分型及临床应用的研究进展  

Research progress on molecular typing and clinical application of endometrial carcinoma

作　　者：陈曦[1] 古艳菲 林伟钊 朱耀魁[1] CHEN Xi;GU Yanfei;LIN Weizhao;ZHU Yaokui(Department of Obstetrics and Gynecology,the First Affiliated Hospital of Jinan University,Guangzhou,Guangdong 510630,China)

机构地区：[1]暨南大学附属第一医院妇产科,广东广州510630

出　　处：《现代医药卫生》2025年第2期474-479,共6页Journal of Modern Medicine & Health

基　　金：广东省医学科学技术研究基金项目(A2022369);广东省中医药局科研项目(20241068)。

摘　　要：近年来,子宫内膜癌(EC)发病率呈逐渐升高趋势,且晚期/复发性EC预后较差,以传统形态学特征为核心进行诊治,无法满足精准治疗的需求。目前,国内外指南均已将分子分型融入预后风险分组中,可在传统分类中筛选出不同风险程度的亚型,用于指导EC手术方式的选择及药物治疗,避免早期EC出现过度治疗或治疗不足情况,开拓了晚期/复发性EC联合治疗的新思路,对EC的个体化诊疗具有重大意义。该文基于分子分型最新研究进展及其特点阐述了其在EC中的临床应用进展。In recent years,the incidence of endometrial cancer(EC)has gradually increased,and the prognosis of advanced/recurrent EC is poor.The traditional morphological characteristics as the core of diagnosis and treatment can not meet the needs of precise treatment.At present,the guidelines at home and abroad have integrated molecular typing into the prognosis risk grouping,which can screen out the subtypes with different risk levels in the traditional classification,which can be used to guide the selection of surgical methods and drug treatment of EC,avoid over treatment or insufficient treatment in early EC,and open up a new idea of combined treatment of late/recurrent EC,which is of great significance for the individualized diagnosis and treatment of EC.Based on the latest research progress and characteristics of molecular typing,the paper expounded its clinical application progress in EC.

关 键 词：子宫内膜癌 分子分型 复发 个体化治疗 综述 

分 类 号：R737.33[医药卫生—肿瘤]