M受体信号通路在近视发生发展中作用的研究进展  

Research progress on the role of M receptor signaling pathway in the occurrence and development of myopia

作　　者：张金木 郭滨[1,2] 蒋文君 刘冬梅[4] ZHANG Jinmu;GUO Bin;JIANG Wenjun;LIU Dongmei(College of Ophthalmology and Optometry,Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,China;Postdoctoral Station of Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,China;Shandong Academy of Eye Disease Prevention and Therapy/Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Eye Disease,Jinan 250002,Shandong,China;Department of Cataract,Eye Hospital Affiliated to Shandong University of Traditional Chinese Medicine,Jinan 250002,Shandong,China)

机构地区：[1]山东中医药大学眼科与视光医学院,山东济南250355 [2]山东中医药大学博士后流动站,山东济南250355 [3]山东省眼病防治研究院实验中心/山东省中西医结合眼病防治重点实验室,山东济南250002 [4]山东中医药大学附属眼科医院白内障科,山东济南250002

出　　处：《山东大学耳鼻喉眼学报》2024年第5期160-164,共5页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：国家重点研发计划(2021YFC2702103);山东省自然科学基金面上项目(ZR2020MH393);山东省博士后创新项目(202101012)

摘　　要：M受体参与调节众多眼组织生理活动。研究表明,M受体可通过调节睫状肌收缩、调控视网膜和脉络膜中近视相关神经递质(如多巴胺)和生长因子(如转化生长因子β2)的表达来影响巩膜成纤维细胞增殖和基质金属蛋白酶2水平,进而影响巩膜重塑和眼轴增长,最终影响近视的发生发展。近年来,大量动物实验及临床研究均证实M受体拮抗剂可有效延缓近视进展。论文就不同眼组织(睫状肌、视网膜、脉络膜和巩膜)中M受体信号通路在近视发生发展中的作用进行简要综述,以期为近视相关机制研究及临床治疗提供思路。M receptors participate in regulating numerous physiological activities in eye tissues.Studies have shown that M receptors can regulate ciliary muscle contraction,regulate the expression of myopia-related neurotransmitters(such as dopamine)and growth factors(such as transforming growth factorβ2)in the retina and choroid,and affect scleral fibroblast proliferation and matrix metalloproteinase-2 expression,which in turn affects scleral remodeling and axial growth,ultimately affecting the occurrence and development of myopia.In recent years,a large number of animal experiments and clinical studies have confirmed that M receptor antagonists effectively delay the progression of myopia.This article provides a brief review of the role of the M receptor signaling pathway in the occurrence and development of myopia in different eye tissues(ciliary muscle,retina,choroid,and sclera),to provide ideas for the studing of myopia-related mechanisms and clinical treatment.

关 键 词：近视 M受体 睫状肌 视网膜 脉络膜 巩膜 

分 类 号：R778.11[医药卫生—眼科]