Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate  

作　　者：Ghofran Hadi Mashkour Sangar Naser Mirazi Nasim Hayati Roodbari Abdolkarim Hossieni 

机构地区：[1]Department of Biology,Faculty of Basic Sciences,Islamic Azad University,Science and Research Branch,Tehran,Iran [2]Department of Biology,Faculty of Basic Sciences,Bu-Ali Sina University,Hamedan,Iran [3]Department of Animal Sciences and Marine Biology,Faculty of Life Sciences and Biotechnology,Shahid Beheshti University,Tehran,Iran

出　　处：《World Journal of Traditional Chinese Medicine》2024年第4期476-484,共9页世界中医药杂志(英文)

摘　　要：Objective:Polycystic ovary syndrome(PCOS) is the most prevalent endocrine disorder in women of reproductive age.The objective of our investigation is to study the protective effect of hydroethanolic extract of palm meristem(HEPM) on female rats with PCOS.Materials and Methods:The experimental study involved the placement of 42 adult female Wistar rats(n=7) into six groups,with the control group rcceiving 0.25 ml of physiological serum by gavage daily,the sham group getting 0.25 ml of olive oil,and the HEPM 250,500,and 500 per se group taking HEPM by gavage daily.PCOS was induced with estradiol valerate(EV),which was administered through a subcutaneous inj ection at 2 mg/kg volume using 0.25 ml of olive oil.After experiments,all animals were subj ected to anesthe sia,and serums were extracted for biochemical and ho rmonal evaluation.Results:EV showed marked increases in serum levels of testosterone and luteinizing hormone when compared with the control group.Significantly,the EV group decreased 17-β estradiol,proge sterone,and follicle-stimulating hormone.There was a significant alteration in hormonal levels across the treatment groups.The serum malondialdehyde levels and total oxidant status were elevated in the EV group.In addition,the serum levels of total antioxidant capacity,glutathione,and glutathione peroxidase were significantly lower in the EV group than in control rats.In the treatment groups,HEPM significantly reverses the oxidant/antioxidant balance and ameliorates the adverse effect of PCOS on oxidative stress.Conclusion:The study findings indicated that the HEPM effectively safeguarded ovarian tissue from developing PCOS in the presence of EV.

关 键 词：Estradiol valerate Phoenix dactylifera polycystic ovary syndrome RAT 

分 类 号：R285.5[医药卫生—中药学]